TY - JOUR
T1 - Microbial transformations of Isocupressic acid
AU - Lin, Shwu Jiuan
AU - Rosazza, J. P N
PY - 1998/7
Y1 - 1998/7
N2 - Microbial transformations of the labdane-diterpene isocupressic acid (1) with different microorganisms yielded several oxygenated metabolites that were isolated and characterized by MS and NMR spectroscopic analyses. Nocardia aurantia (ATCC 12674) catalyzed the cleavage of the 13,14-double bond to yield a new nor-labdane metabolite, 2. Cunninghamella elegans (-) (NRRL 1393) gave 7β-hydroxyisocupressic acid (3) and labda-7,13(E)-diene- 6β,15,17-triol-19-oic acid (4), and Mucor mucedo (ATCC 20094) gave 2α- hydroxyisocupressic acid (5) and labda-8(17),14-diene-2α,13-diol-19-oic acid (6).
AB - Microbial transformations of the labdane-diterpene isocupressic acid (1) with different microorganisms yielded several oxygenated metabolites that were isolated and characterized by MS and NMR spectroscopic analyses. Nocardia aurantia (ATCC 12674) catalyzed the cleavage of the 13,14-double bond to yield a new nor-labdane metabolite, 2. Cunninghamella elegans (-) (NRRL 1393) gave 7β-hydroxyisocupressic acid (3) and labda-7,13(E)-diene- 6β,15,17-triol-19-oic acid (4), and Mucor mucedo (ATCC 20094) gave 2α- hydroxyisocupressic acid (5) and labda-8(17),14-diene-2α,13-diol-19-oic acid (6).
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U2 - 10.1021/np980064b
DO - 10.1021/np980064b
M3 - Article
C2 - 9677275
AN - SCOPUS:0031879196
SN - 0163-3864
VL - 61
SP - 922
EP - 926
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 7
ER -