摘要
原文 | 英語 |
---|---|
文章編號 | e0216367 |
期刊 | PLoS One |
卷 | 14 |
發行號 | 5 |
DOIs | |
出版狀態 | 已發佈 - 五月 1 2019 |
指紋
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)
引用此文
Microbial etiology of pneumonia in patients with decreased renal function. / Chen, Chun you; Hsu, Shih chang; Hsieh, Hui ling; Suk, Chi won; Hsu, Yuan pin; Sue, Yuh mou; Chen, Tso Hsiao; Lin, Feng yen; Shih, Chun ming; Chen, Jaw wen; Lin, Shing jong; Huang, Po hsun; Liu, Chung te.
於: PLoS One, 卷 14, 編號 5, e0216367, 01.05.2019.研究成果: 雜誌貢獻 › 文章
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TY - JOUR
T1 - Microbial etiology of pneumonia in patients with decreased renal function
AU - Chen, Chun you
AU - Hsu, Shih chang
AU - Hsieh, Hui ling
AU - Suk, Chi won
AU - Hsu, Yuan pin
AU - Sue, Yuh mou
AU - Chen, Tso Hsiao
AU - Lin, Feng yen
AU - Shih, Chun ming
AU - Chen, Jaw wen
AU - Lin, Shing jong
AU - Huang, Po hsun
AU - Liu, Chung te
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Background Patients with renal impairment have altered immunity, which might cause vulnerability to specific pathogens and worsen pneumonia-related outcomes. Nonetheless, the microbiological features of pneumonia in patients with decreased renal function remain unknown. Methods Therefore, we conducted a retrospective cohort study enrolling adult patients hospitalized with pneumonia to assess this knowledge gap. The baseline estimated glomerular filtration rate (eGFR) and first sputum microbiology during hospitalization were used for statistical analyses. Results Overall, 1554 patients hospitalized with pneumonia (mean age, 76.1 ± 16.7) were included, and 162 patients had died at the end of hospitalization. The cutoff eGFR value predicting mortality was <55 mL/min/1.73 m 2 , which defined decreased renal function in this study. Patients with decreased renal function demonstrated a significantly higher risk of fungi and Staphylococcus aureus (S. aureus) infection. On the other hand, this group of patients showed significantly higher neutrophil-to-lymphocyte ratio (NLR), which associated with higher mortality. Additionally, patients with S. aureus had a significantly lower eGFR, lymphocyte count and a higher NLR. Conclusions These findings suggested the altered immunity and vulnerability to S. aureus infection in patients with decreased renal function, which may be the underlying cause of worse outcomes of pneumonia in this group of patients.
AB - Background Patients with renal impairment have altered immunity, which might cause vulnerability to specific pathogens and worsen pneumonia-related outcomes. Nonetheless, the microbiological features of pneumonia in patients with decreased renal function remain unknown. Methods Therefore, we conducted a retrospective cohort study enrolling adult patients hospitalized with pneumonia to assess this knowledge gap. The baseline estimated glomerular filtration rate (eGFR) and first sputum microbiology during hospitalization were used for statistical analyses. Results Overall, 1554 patients hospitalized with pneumonia (mean age, 76.1 ± 16.7) were included, and 162 patients had died at the end of hospitalization. The cutoff eGFR value predicting mortality was <55 mL/min/1.73 m 2 , which defined decreased renal function in this study. Patients with decreased renal function demonstrated a significantly higher risk of fungi and Staphylococcus aureus (S. aureus) infection. On the other hand, this group of patients showed significantly higher neutrophil-to-lymphocyte ratio (NLR), which associated with higher mortality. Additionally, patients with S. aureus had a significantly lower eGFR, lymphocyte count and a higher NLR. Conclusions These findings suggested the altered immunity and vulnerability to S. aureus infection in patients with decreased renal function, which may be the underlying cause of worse outcomes of pneumonia in this group of patients.
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U2 - 10.1371/journal.pone.0216367
DO - 10.1371/journal.pone.0216367
M3 - Article
C2 - 31071139
AN - SCOPUS:85065675966
VL - 14
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 5
M1 - e0216367
ER -