Microbial etiology of pneumonia in patients with decreased renal function

Chun you Chen, Shih chang Hsu, Hui ling Hsieh, Chi won Suk, Yuan pin Hsu, Yuh mou Sue, Tso Hsiao Chen, Feng yen Lin, Chun ming Shih, Jaw wen Chen, Shing jong Lin, Po hsun Huang, Chung te Liu

研究成果: 雜誌貢獻 › 文章

摘要

Background Patients with renal impairment have altered immunity, which might cause vulnerability to specific pathogens and worsen pneumonia-related outcomes. Nonetheless, the microbiological features of pneumonia in patients with decreased renal function remain unknown. Methods Therefore, we conducted a retrospective cohort study enrolling adult patients hospitalized with pneumonia to assess this knowledge gap. The baseline estimated glomerular filtration rate (eGFR) and first sputum microbiology during hospitalization were used for statistical analyses. Results Overall, 1554 patients hospitalized with pneumonia (mean age, 76.1 ± 16.7) were included, and 162 patients had died at the end of hospitalization. The cutoff eGFR value predicting mortality was <55 mL/min/1.73 m 2 , which defined decreased renal function in this study. Patients with decreased renal function demonstrated a significantly higher risk of fungi and Staphylococcus aureus (S. aureus) infection. On the other hand, this group of patients showed significantly higher neutrophil-to-lymphocyte ratio (NLR), which associated with higher mortality. Additionally, patients with S. aureus had a significantly lower eGFR, lymphocyte count and a higher NLR. Conclusions These findings suggested the altered immunity and vulnerability to S. aureus infection in patients with decreased renal function, which may be the underlying cause of worse outcomes of pneumonia in this group of patients.
原文英語
文章編號e0216367
期刊PLoS One
卷14
發行號5
DOIs
出版狀態已發佈 - 五月 1 2019

指紋

renal function
pneumonia
Lymphocytes
etiology
Pneumonia
Kidney
glomerular filtration rate
Microbiology
Glomerular Filtration Rate
Pathogens
Staphylococcus aureus
Fungi
neutrophils
Immunity
Hospitalization
Neutrophils
lymphocytes
immunity
Mortality
lymphocyte count

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

引用此文

Microbial etiology of pneumonia in patients with decreased renal function. / Chen, Chun you; Hsu, Shih chang; Hsieh, Hui ling; Suk, Chi won; Hsu, Yuan pin; Sue, Yuh mou; Chen, Tso Hsiao; Lin, Feng yen; Shih, Chun ming; Chen, Jaw wen; Lin, Shing jong; Huang, Po hsun; Liu, Chung te.

於: PLoS One, 卷 14, 編號 5, e0216367, 01.05.2019.

研究成果: 雜誌貢獻 › 文章

Chen, CY, Hsu, SC, Hsieh, HL, Suk, CW, Hsu, YP, Sue, YM, Chen, TH, Lin, FY, Shih, CM, Chen, JW, Lin, SJ, Huang, PH & Liu, CT 2019, 'Microbial etiology of pneumonia in patients with decreased renal function', PLoS One, 卷 14, 編號 5, e0216367. https://doi.org/10.1371/journal.pone.0216367
Chen CY, Hsu SC, Hsieh HL, Suk CW, Hsu YP, Sue YM 等. Microbial etiology of pneumonia in patients with decreased renal function. PLoS One. 2019 5月 1;14(5). e0216367. https://doi.org/10.1371/journal.pone.0216367
Chen, Chun you ; Hsu, Shih chang ; Hsieh, Hui ling ; Suk, Chi won ; Hsu, Yuan pin ; Sue, Yuh mou ; Chen, Tso Hsiao ; Lin, Feng yen ; Shih, Chun ming ; Chen, Jaw wen ; Lin, Shing jong ; Huang, Po hsun ; Liu, Chung te. / Microbial etiology of pneumonia in patients with decreased renal function. 於: PLoS One. 2019 ; 卷 14, 編號 5.
@article{3c2e34d878c04ff080208333ea2db395,
title = "Microbial etiology of pneumonia in patients with decreased renal function",
abstract = "Background Patients with renal impairment have altered immunity, which might cause vulnerability to specific pathogens and worsen pneumonia-related outcomes. Nonetheless, the microbiological features of pneumonia in patients with decreased renal function remain unknown. Methods Therefore, we conducted a retrospective cohort study enrolling adult patients hospitalized with pneumonia to assess this knowledge gap. The baseline estimated glomerular filtration rate (eGFR) and first sputum microbiology during hospitalization were used for statistical analyses. Results Overall, 1554 patients hospitalized with pneumonia (mean age, 76.1 ± 16.7) were included, and 162 patients had died at the end of hospitalization. The cutoff eGFR value predicting mortality was <55 mL/min/1.73 m 2 , which defined decreased renal function in this study. Patients with decreased renal function demonstrated a significantly higher risk of fungi and Staphylococcus aureus (S. aureus) infection. On the other hand, this group of patients showed significantly higher neutrophil-to-lymphocyte ratio (NLR), which associated with higher mortality. Additionally, patients with S. aureus had a significantly lower eGFR, lymphocyte count and a higher NLR. Conclusions These findings suggested the altered immunity and vulnerability to S. aureus infection in patients with decreased renal function, which may be the underlying cause of worse outcomes of pneumonia in this group of patients.",
author = "Chen, {Chun you} and Hsu, {Shih chang} and Hsieh, {Hui ling} and Suk, {Chi won} and Hsu, {Yuan pin} and Sue, {Yuh mou} and Chen, {Tso Hsiao} and Lin, {Feng yen} and Shih, {Chun ming} and Chen, {Jaw wen} and Lin, {Shing jong} and Huang, {Po hsun} and Liu, {Chung te}",
year = "2019",
month = "5",
day = "1",
doi = "10.1371/journal.pone.0216367",
language = "English",
volume = "14",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",

}

TY - JOUR

T1 - Microbial etiology of pneumonia in patients with decreased renal function

AU - Chen, Chun you

AU - Hsu, Shih chang

AU - Hsieh, Hui ling

AU - Suk, Chi won

AU - Hsu, Yuan pin

AU - Sue, Yuh mou

AU - Chen, Tso Hsiao

AU - Lin, Feng yen

AU - Shih, Chun ming

AU - Chen, Jaw wen

AU - Lin, Shing jong

AU - Huang, Po hsun

AU - Liu, Chung te

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Background Patients with renal impairment have altered immunity, which might cause vulnerability to specific pathogens and worsen pneumonia-related outcomes. Nonetheless, the microbiological features of pneumonia in patients with decreased renal function remain unknown. Methods Therefore, we conducted a retrospective cohort study enrolling adult patients hospitalized with pneumonia to assess this knowledge gap. The baseline estimated glomerular filtration rate (eGFR) and first sputum microbiology during hospitalization were used for statistical analyses. Results Overall, 1554 patients hospitalized with pneumonia (mean age, 76.1 ± 16.7) were included, and 162 patients had died at the end of hospitalization. The cutoff eGFR value predicting mortality was <55 mL/min/1.73 m 2 , which defined decreased renal function in this study. Patients with decreased renal function demonstrated a significantly higher risk of fungi and Staphylococcus aureus (S. aureus) infection. On the other hand, this group of patients showed significantly higher neutrophil-to-lymphocyte ratio (NLR), which associated with higher mortality. Additionally, patients with S. aureus had a significantly lower eGFR, lymphocyte count and a higher NLR. Conclusions These findings suggested the altered immunity and vulnerability to S. aureus infection in patients with decreased renal function, which may be the underlying cause of worse outcomes of pneumonia in this group of patients.

AB - Background Patients with renal impairment have altered immunity, which might cause vulnerability to specific pathogens and worsen pneumonia-related outcomes. Nonetheless, the microbiological features of pneumonia in patients with decreased renal function remain unknown. Methods Therefore, we conducted a retrospective cohort study enrolling adult patients hospitalized with pneumonia to assess this knowledge gap. The baseline estimated glomerular filtration rate (eGFR) and first sputum microbiology during hospitalization were used for statistical analyses. Results Overall, 1554 patients hospitalized with pneumonia (mean age, 76.1 ± 16.7) were included, and 162 patients had died at the end of hospitalization. The cutoff eGFR value predicting mortality was <55 mL/min/1.73 m 2 , which defined decreased renal function in this study. Patients with decreased renal function demonstrated a significantly higher risk of fungi and Staphylococcus aureus (S. aureus) infection. On the other hand, this group of patients showed significantly higher neutrophil-to-lymphocyte ratio (NLR), which associated with higher mortality. Additionally, patients with S. aureus had a significantly lower eGFR, lymphocyte count and a higher NLR. Conclusions These findings suggested the altered immunity and vulnerability to S. aureus infection in patients with decreased renal function, which may be the underlying cause of worse outcomes of pneumonia in this group of patients.

UR - http://www.scopus.com/inward/record.url?scp=85065675966&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065675966&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0216367

DO - 10.1371/journal.pone.0216367

M3 - Article

VL - 14

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 5

M1 - e0216367

ER -

存取文件