Metoclopramide Therapy and Movement Disorders in a Diabetic-Uremic Subject With Bilateral Basal Ganglia Lesions

Chun Sum Ho, Rey Yue Yuan, His Hsien Chen, Jia Ming Yu, Jau Jiuan Sheu

研究成果: 雜誌貢獻文章同行評審

摘要

The etiologies of the syndrome of acute bilateral basal ganglia lesions in diabetic-uremic subjects have been postulated to involve metabolic and/or vascular factors related to diabetes mellitus, uremic toxins, metabolic acidosis, and hypoxemia. The role of dopamine receptor antagonists in the pathophysiology of this disorder has never been discussed before. We present a diabetic-uremic subject who developed bilateral basal ganglia lesions and involuntary movements after metoclopramide therapy. All workup test results were negative except that for impaired renal function. The involuntary movements disappeared after discontinuation of metoclopramide. She developed acute parkinsonism with gait disturbance after metoclopramide therapy several months after the first episode. Her gait gradually improved after discontinuation of metoclopramide. We suggests that metoclopramide therapy may further damage the vulnerable basal ganglia and lead to drug-induced parkinsonism and also the syndrome of acute bilateral basal ganglia lesions in this diabetic-uremic subject. Dopamine receptor antagonists should be avoided or used with caution in subjects with diabetes and uremia.

原文英語
頁(從 - 到)50-52
頁數3
期刊Journal of Experimental and Clinical Medicine(Taiwan)
3
發行號1
DOIs
出版狀態已發佈 - 二月 2011

ASJC Scopus subject areas

  • 醫藥 (全部)

指紋

深入研究「Metoclopramide Therapy and Movement Disorders in a Diabetic-Uremic Subject With Bilateral Basal Ganglia Lesions」主題。共同形成了獨特的指紋。

引用此