Methionine synthase 2756AA polymorphism is associated with the risk of cognitive impairment in patients with late-life depression

Ya Hsu Yang, Chih Chiang Chiu, Hao Wei Teng, Chih Pang Chu, Ching Jui Chang, Wei Che Chiu, Chin Hsin Chen, Mong Liang Lu, Shen Ing Liu, Shih Yi Huang, Hsing Cheng Liu, I. Wen Sun

研究成果: 雜誌貢獻文章


Backgrounds: Apolipoprotein E epsilon-4 (APOE ε4) allele, methylenetetrahydrofolate reductase (MTHFR C677T), and methionine synthase (MTR A2756G) were tested their associations with cognitive impairment in people with late-life depression (LLD). Methods: People with LLD were assessed by mini-mental state examination and were examined the distribution of APOE ε4 allele, MTHFR, and MTR polymorphisms. Results: Odds ratio of MTR 2756 AA to MTR 2756 AG and GG genotypes for the risk of cognitive impairment was 5.80 (95% confidence interval=1.18-28.50; P=0.03). Conclusion: People with LLD carrying MTR2756 AA genotype have higher risk of cognitive impairment than those carrying G allele.
期刊Asia-Pacific Psychiatry
出版狀態已發佈 - 三月 1 2017


ASJC Scopus subject areas

  • Psychiatry and Mental health