Methicillin-resistant Staphylococcus aureus bacteraemia in neonatal intensive care units: An analysis of 90 episodes

Y. Y. Chuang, Y. C. Huang, C. Y. Lee, T. Y. Lin, R. Lien, Y. H. Chou

研究成果: 雜誌貢獻回顧型文獻

39 引文 (Scopus)

摘要

Aim: To delineate the clinical features of methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia in infants hospitalized at the neonatal intensive care unit. Methods: Episodes of MRSA bacteraemia in Chang Gung Children's Hospital neonatal intensive care unit from 1997 to 1999 were reviewed for incidence, predisposing factors, clinical presentations, treatment and outcome. Results: Ninety episodes of MRSA bacteraemia were identified. The overall rate of MRSA bacteraemia was 1.05 per 1000 patient days during the 3-y period. Most of the patients were premature infants (76%), with prior operation or invasive procedures (39%), had an indwelling intravascular catheter (79%) and exposure to antibiotic therapy (96%). A localized cutaneous infection was found in 53.3% of the episodes. The most common clinical diagnoses were catheter-related infections (54.4%), skin and soft tissue infections (21.1%), bacteraemia without a focus (20%) and pneumonia (16.7%). Metastatic infection occurred in 18% of these infants. Among the patients treated with vancomycin for ≤14 d, 88.7% did not develop any complications, and 11.3% developed a recurrence. Conclusions: MRSA is an established pathogen in our NICU. MRSA bacteraemia in the neonates predominantly presented as catheter-related infections, and metastatic infections were not infrequently seen. In uncomplicated MRSA bacteraemia, treatment with vancomycin for ≤14 d seems to be adequate.
原文英語
頁(從 - 到)786-790
頁數5
期刊Acta Paediatrica, International Journal of Paediatrics
93
發行號6
DOIs
出版狀態已發佈 - 六月 2004
對外發佈Yes

指紋

Neonatal Intensive Care Units
Methicillin-Resistant Staphylococcus aureus
Bacteremia
Catheter-Related Infections
Vancomycin
Infection
Skin
Soft Tissue Infections
Indwelling Catheters
Premature Infants
Causality
Pneumonia
Newborn Infant
Anti-Bacterial Agents
Recurrence
Incidence
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

引用此文

Methicillin-resistant Staphylococcus aureus bacteraemia in neonatal intensive care units : An analysis of 90 episodes. / Chuang, Y. Y.; Huang, Y. C.; Lee, C. Y.; Lin, T. Y.; Lien, R.; Chou, Y. H.

於: Acta Paediatrica, International Journal of Paediatrics, 卷 93, 編號 6, 06.2004, p. 786-790.

研究成果: 雜誌貢獻回顧型文獻

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abstract = "Aim: To delineate the clinical features of methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia in infants hospitalized at the neonatal intensive care unit. Methods: Episodes of MRSA bacteraemia in Chang Gung Children's Hospital neonatal intensive care unit from 1997 to 1999 were reviewed for incidence, predisposing factors, clinical presentations, treatment and outcome. Results: Ninety episodes of MRSA bacteraemia were identified. The overall rate of MRSA bacteraemia was 1.05 per 1000 patient days during the 3-y period. Most of the patients were premature infants (76{\%}), with prior operation or invasive procedures (39{\%}), had an indwelling intravascular catheter (79{\%}) and exposure to antibiotic therapy (96{\%}). A localized cutaneous infection was found in 53.3{\%} of the episodes. The most common clinical diagnoses were catheter-related infections (54.4{\%}), skin and soft tissue infections (21.1{\%}), bacteraemia without a focus (20{\%}) and pneumonia (16.7{\%}). Metastatic infection occurred in 18{\%} of these infants. Among the patients treated with vancomycin for ≤14 d, 88.7{\%} did not develop any complications, and 11.3{\%} developed a recurrence. Conclusions: MRSA is an established pathogen in our NICU. MRSA bacteraemia in the neonates predominantly presented as catheter-related infections, and metastatic infections were not infrequently seen. In uncomplicated MRSA bacteraemia, treatment with vancomycin for ≤14 d seems to be adequate.",
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T2 - An analysis of 90 episodes

AU - Chuang, Y. Y.

AU - Huang, Y. C.

AU - Lee, C. Y.

AU - Lin, T. Y.

AU - Lien, R.

AU - Chou, Y. H.

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N2 - Aim: To delineate the clinical features of methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia in infants hospitalized at the neonatal intensive care unit. Methods: Episodes of MRSA bacteraemia in Chang Gung Children's Hospital neonatal intensive care unit from 1997 to 1999 were reviewed for incidence, predisposing factors, clinical presentations, treatment and outcome. Results: Ninety episodes of MRSA bacteraemia were identified. The overall rate of MRSA bacteraemia was 1.05 per 1000 patient days during the 3-y period. Most of the patients were premature infants (76%), with prior operation or invasive procedures (39%), had an indwelling intravascular catheter (79%) and exposure to antibiotic therapy (96%). A localized cutaneous infection was found in 53.3% of the episodes. The most common clinical diagnoses were catheter-related infections (54.4%), skin and soft tissue infections (21.1%), bacteraemia without a focus (20%) and pneumonia (16.7%). Metastatic infection occurred in 18% of these infants. Among the patients treated with vancomycin for ≤14 d, 88.7% did not develop any complications, and 11.3% developed a recurrence. Conclusions: MRSA is an established pathogen in our NICU. MRSA bacteraemia in the neonates predominantly presented as catheter-related infections, and metastatic infections were not infrequently seen. In uncomplicated MRSA bacteraemia, treatment with vancomycin for ≤14 d seems to be adequate.

AB - Aim: To delineate the clinical features of methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia in infants hospitalized at the neonatal intensive care unit. Methods: Episodes of MRSA bacteraemia in Chang Gung Children's Hospital neonatal intensive care unit from 1997 to 1999 were reviewed for incidence, predisposing factors, clinical presentations, treatment and outcome. Results: Ninety episodes of MRSA bacteraemia were identified. The overall rate of MRSA bacteraemia was 1.05 per 1000 patient days during the 3-y period. Most of the patients were premature infants (76%), with prior operation or invasive procedures (39%), had an indwelling intravascular catheter (79%) and exposure to antibiotic therapy (96%). A localized cutaneous infection was found in 53.3% of the episodes. The most common clinical diagnoses were catheter-related infections (54.4%), skin and soft tissue infections (21.1%), bacteraemia without a focus (20%) and pneumonia (16.7%). Metastatic infection occurred in 18% of these infants. Among the patients treated with vancomycin for ≤14 d, 88.7% did not develop any complications, and 11.3% developed a recurrence. Conclusions: MRSA is an established pathogen in our NICU. MRSA bacteraemia in the neonates predominantly presented as catheter-related infections, and metastatic infections were not infrequently seen. In uncomplicated MRSA bacteraemia, treatment with vancomycin for ≤14 d seems to be adequate.

KW - Bacteraemia

KW - Methicillin-resistant Staphylococcus aureus

KW - Neonatal intensive care units

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