Methamphetamine downregulates peroxiredoxins in rat pheochromocytoma cells

Han Min Chen, Yi Chao Lee, Chuen Lin Huang, Hui Kang Liu, Wei Chen Liao, Wen Lin Lai, Yen Ru Lin, Nai Kuei Huang

研究成果: 雜誌貢獻文章同行評審

12 引文 斯高帕斯(Scopus)

摘要

Methamphetamine (METH) is an abusive psychostimulant that induces neuronal cell death/degeneration in experimental animals and humans. METH-induced apoptosis in rat pheochromocytoma cells was utilized to study the neurotoxic mechanism. During METH intoxication, we found that peroxiredoxins and thioredoxins/thioredoxin reductases (peroxiredoxin reducing systems) which are known to prevent oxidative stress and apoptosis were differentially downregulated and upregulated, respectively. We also found not only the free radicals but also the oxidative forms of peroxiredoxin and thioredoxin were increased, indicating the dysfunction of these enzymes. Thus, METH-induced differential regulation and oxidation of peroxiredoxins and thioredoxin may be an important mechanism for apoptosis.

原文英語
頁(從 - 到)96-101
頁數6
期刊Biochemical and Biophysical Research Communications
354
發行號1
DOIs
出版狀態已發佈 - 三月 2 2007
對外發佈

ASJC Scopus subject areas

  • 生物化學
  • 生物物理學
  • 分子生物學

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