Metabolism of urea and glyoxylate, degradative products of purines in marine animals

Tomoo Noguchi, Satoko Fujiwara, Yoshikazu Takada, Toshio Mori, Miyota Nagano

研究成果: 雜誌貢獻文章

6 引文 (Scopus)

摘要

In marine fish and crustacean liver, degradative enzymes able to convert purines to urate have been shown to be located only in the cytosol, and degradative enzymes able to convert urate to urea and glyoxylate, only in the peroxisomes (Noguchi, T., Takada, Y., & Fujiwara, S. (1979) J. Biol. Chem. 254, 5272-5275). The subcellular distribution of these two enzymes involved in further metabolism of urea and glyoxylate in marine animal species was examined by centrifugation in a sucrose density gradient.Urease was located only in the cytosol of crustacean and mollusc liver; no activity was detected with fish liver.In fish, crustacean and mollusc liver, the conversion of glyoxylate to glycine may be mainly catalyzed by alanine: glyoxylate aminotransferase. Hepatic alanine: glyoxylate aminotransferase was located both in the mitochondrial matrix and in the cytosol in each species studied.These findings suggest that peroxisomal urea is transported to the cytosol then degraded to NH3 for the excretion of purine nitrogens, while peroxisomal glyoxylate is transported to the cytosol or mitochondria then converted to glycine for the reutilization of purine carbons.

原文英語
頁(從 - 到)525-529
頁數5
期刊Journal of Biochemistry
92
發行號2
出版狀態已發佈 - 1982
對外發佈Yes

指紋

Purines
Metabolism
Urea
Liver
Cytosol
Animals
Fish
Molluscs
Enzymes
Uric Acid
Fishes
Glycine
Mollusca
Convert
Amino acids
Mitochondria
Centrifugation
Urease
Sugar (sucrose)
Sucrose

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Radiology Nuclear Medicine and imaging
  • Molecular Biology
  • Biochemistry

引用此文

Noguchi, T., Fujiwara, S., Takada, Y., Mori, T., & Nagano, M. (1982). Metabolism of urea and glyoxylate, degradative products of purines in marine animals. Journal of Biochemistry, 92(2), 525-529.

Metabolism of urea and glyoxylate, degradative products of purines in marine animals. / Noguchi, Tomoo; Fujiwara, Satoko; Takada, Yoshikazu; Mori, Toshio; Nagano, Miyota.

於: Journal of Biochemistry, 卷 92, 編號 2, 1982, p. 525-529.

研究成果: 雜誌貢獻文章

Noguchi, T, Fujiwara, S, Takada, Y, Mori, T & Nagano, M 1982, 'Metabolism of urea and glyoxylate, degradative products of purines in marine animals', Journal of Biochemistry, 卷 92, 編號 2, 頁 525-529.
Noguchi T, Fujiwara S, Takada Y, Mori T, Nagano M. Metabolism of urea and glyoxylate, degradative products of purines in marine animals. Journal of Biochemistry. 1982;92(2):525-529.
Noguchi, Tomoo ; Fujiwara, Satoko ; Takada, Yoshikazu ; Mori, Toshio ; Nagano, Miyota. / Metabolism of urea and glyoxylate, degradative products of purines in marine animals. 於: Journal of Biochemistry. 1982 ; 卷 92, 編號 2. 頁 525-529.
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