Mesoporous silica nanoparticles functionalized with an oxygen-sensing probe for cell photodynamic therapy: Potential cancer theranostics

Shih Hsun Cheng, Chia Hung Lee, Chung Shi Yang, Fan Gang Tseng, Chung Yuan Mou, Leu Wei Lo

研究成果: 雜誌貢獻文章同行評審

134 引文 斯高帕斯(Scopus)

摘要

Functionalization of mesoporous silica nanoparticles (MSNs) with Pd-porphyrins for cancer cell photodynamic therapy is reported. The composite platform, MSN-PdTPP, expands the role of Pd-porphyrins from their routine use as phosphorescence probes for oxygen sensing/imaging (diagnostics) to that of novel nano-photosensitizers for cancer cell phototherapy (therapeutics). The utility of MSN-PdTPP in the phototherapeutic treatment of MDA-MB-231 breast cancer cells is also evaluated, suggesting it is a promising cancer theranostic platform.

原文英語
頁(從 - 到)1252-1257
頁數6
期刊Journal of Materials Chemistry
19
發行號9
DOIs
出版狀態已發佈 - 2009
對外發佈

ASJC Scopus subject areas

  • 化學 (全部)
  • 材料化學

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