Mesenchymal stem cell therapy for nonmusculoskeletal diseases: Emerging applications

Tom K. Kuo, Jennifer H. Ho, Oscar K. Lee

研究成果: 雜誌貢獻文章同行評審

49 引文 斯高帕斯(Scopus)

摘要

Mesenchymal stem cells are stem/progenitor cells originated from the mesoderm and can different into multiple cell types of the musculoskeletal system. The vast differentiation potential and the relative ease for culture expansion have established mesenchymal stem cells as the building blocks in cell therapy and tissue engineering applications for a variety of musculoskeletal diseases, including repair of fractures and bone defects, cartilage regeneration, treatment of osteonecrosis of the femoral head, and correction of genetic diseases such as osteogenesis imperfect. However, research in the past decade has revealed differentiation potentials of mesenchymal stem cells beyond lineages of the mesoderm, suggesting broader applications than originally perceived. In this article, we review the recent developments in mesenchymal stem cell research with respect to their emerging properties and applications in nonmusculoskeletal diseases.
原文英語
頁(從 - 到)1013-1028
頁數16
期刊Cell Transplantation
18
發行號9
DOIs
出版狀態已發佈 - 2009

ASJC Scopus subject areas

  • Cell Biology
  • Biomedical Engineering
  • Transplantation

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