Mesenchymal stem cell attachment to peptide density gradients on porous silicon generated by electrografting

Lauren R. Clements, Peng Yuan Wang, Frances Harding, Wei Bor Tsai, Helmut Thissen, Nicolas H. Voelcker

研究成果: 雜誌貢獻文章同行評審

29 引文 斯高帕斯(Scopus)

摘要

Chemical gradients of ethyl-6-bromohexanoate (EBH) were generated over porous silicon (pSi) substrates via electrochemical attachment. Immobilised ester moieties were hydrolysed and activated to produce a gradient of functional carboxylic acid groups. After subsequent immobilisation of cyclic RGD (cRGD), the surfaces were used to screen the extent of rat mesenchymal stem cell (MSC) attachment. Mapping of surface chemistry was carried out by means of infrared microscopy and X-ray photoelectron spectroscopy (XPS). MSC culture studies showed that short-term cell attachment responded to the cRGD density present on the gradient surface.
原文英語
頁(從 - 到)1440-1445
頁數6
期刊Physica Status Solidi (A) Applications and Materials Science
208
發行號6
DOIs
出版狀態已發佈 - 6月 2011
對外發佈

ASJC Scopus subject areas

  • 電氣與電子工程
  • 電子、光磁材料
  • 材料化學
  • 凝聚態物理學
  • 表面和介面
  • 表面、塗料和薄膜

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