摘要
(-)-Menthol ([1-α]-5-methyl-2-[1-methylethyl]-cyclohexanol), is a widely used flavoring ingredient in mouthwash, foods, toothpaste and cigarettes. The studies reported here revealed that (-)-menthol induced cytotoxicity against murine leukemia WEHI-3 cells in vitro in a dose-dependent manner. The effects of (-)-menthol on WEHI-3 cells in vivo (BALB/c mice) were also examined, and it was observed that the Mac-3 and CD11b markers were decreased, indicating inhibition of differentiation of the precursor of macrophage and granulocyte. The weights of liver and spleen samples from mice treated with (-)-menthol were found to be decreased compared to untreated animals.
原文 | 英語 |
---|---|
頁(從 - 到) | 285-289 |
頁數 | 5 |
期刊 | In Vivo |
卷 | 21 |
發行號 | 2 |
出版狀態 | 已發佈 - 3月 2007 |
ASJC Scopus subject areas
- 生物化學、遺傳與分子生物學 (全部)
- 藥理