(-)-Menthol inhibits WEHI-3 leukemia cells in vitro and in vivo

Hsu Fung Lu; Jia You Liu; Shu Ching Hsueh; Yi Yuan Yang; Jai Sing Yang; Tsu Wei Tan; Lai Fong Kok; Chi Cheng Lu; Sheng Huei Lan; Shan Ying Wu; Shiu Shin Liao; Siu Wan Ip; Jing Gung Chung

(-)-Menthol inhibits WEHI-3 leukemia cells in vitro and in vivo

Hsu Fung Lu, Jia You Liu, Shu Ching Hsueh, Yi Yuan Yang, Jai Sing Yang, Tsu Wei Tan, Lai Fong Kok, Chi Cheng Lu, Sheng Huei Lan, Shan Ying Wu, Shiu Shin Liao, Siu Wan Ip, Jing Gung Chung

研究成果: 雜誌貢獻 › 文章 › 同行評審

26 引文斯高帕斯（Scopus）

摘要

(-)-Menthol ([1-α]-5-methyl-2-[1-methylethyl]-cyclohexanol), is a widely used flavoring ingredient in mouthwash, foods, toothpaste and cigarettes. The studies reported here revealed that (-)-menthol induced cytotoxicity against murine leukemia WEHI-3 cells in vitro in a dose-dependent manner. The effects of (-)-menthol on WEHI-3 cells in vivo (BALB/c mice) were also examined, and it was observed that the Mac-3 and CD11b markers were decreased, indicating inhibition of differentiation of the precursor of macrophage and granulocyte. The weights of liver and spleen samples from mice treated with (-)-menthol were found to be decreased compared to untreated animals.

原文	英語
頁（從 - 到）	285-289
頁數	5
期刊	In Vivo
卷	21
發行號	2
出版狀態	已發佈 - 三月 2007

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology

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(-)-Menthol inhibits WEHI-3 leukemia cells in vitro and in vivo. / Lu, Hsu Fung; Liu, Jia You; Hsueh, Shu Ching; Yang, Yi Yuan; Yang, Jai Sing; Tan, Tsu Wei; Kok, Lai Fong; Lu, Chi Cheng; Lan, Sheng Huei; Wu, Shan Ying; Liao, Shiu Shin; Ip, Siu Wan; Chung, Jing Gung.

於: In Vivo, 卷 21, 編號 2, 03.2007, p. 285-289.

研究成果: 雜誌貢獻 › 文章 › 同行評審

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title = "(-)-Menthol inhibits WEHI-3 leukemia cells in vitro and in vivo",

abstract = "(-)-Menthol ([1-α]-5-methyl-2-[1-methylethyl]-cyclohexanol), is a widely used flavoring ingredient in mouthwash, foods, toothpaste and cigarettes. The studies reported here revealed that (-)-menthol induced cytotoxicity against murine leukemia WEHI-3 cells in vitro in a dose-dependent manner. The effects of (-)-menthol on WEHI-3 cells in vivo (BALB/c mice) were also examined, and it was observed that the Mac-3 and CD11b markers were decreased, indicating inhibition of differentiation of the precursor of macrophage and granulocyte. The weights of liver and spleen samples from mice treated with (-)-menthol were found to be decreased compared to untreated animals.",

keywords = "(-)-Menthol, Apoptosis, BALB/c mice, Cytotoxicity, WEHI-3 leukemia cells",

author = "Lu, {Hsu Fung} and Liu, {Jia You} and Hsueh, {Shu Ching} and Yang, {Yi Yuan} and Yang, {Jai Sing} and Tan, {Tsu Wei} and Kok, {Lai Fong} and Lu, {Chi Cheng} and Lan, {Sheng Huei} and Wu, {Shan Ying} and Liao, {Shiu Shin} and Ip, {Siu Wan} and Chung, {Jing Gung}",

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AU - Lu, Hsu Fung

AU - Liu, Jia You

AU - Hsueh, Shu Ching

AU - Yang, Yi Yuan

AU - Yang, Jai Sing

AU - Tan, Tsu Wei

AU - Kok, Lai Fong

AU - Lu, Chi Cheng

AU - Lan, Sheng Huei

AU - Wu, Shan Ying

AU - Liao, Shiu Shin

AU - Ip, Siu Wan

AU - Chung, Jing Gung

PY - 2007/3

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AB - (-)-Menthol ([1-α]-5-methyl-2-[1-methylethyl]-cyclohexanol), is a widely used flavoring ingredient in mouthwash, foods, toothpaste and cigarettes. The studies reported here revealed that (-)-menthol induced cytotoxicity against murine leukemia WEHI-3 cells in vitro in a dose-dependent manner. The effects of (-)-menthol on WEHI-3 cells in vivo (BALB/c mice) were also examined, and it was observed that the Mac-3 and CD11b markers were decreased, indicating inhibition of differentiation of the precursor of macrophage and granulocyte. The weights of liver and spleen samples from mice treated with (-)-menthol were found to be decreased compared to untreated animals.

KW - (-)-Menthol

KW - Apoptosis

KW - BALB/c mice

KW - Cytotoxicity

KW - WEHI-3 leukemia cells

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