MeDIP-on-chip for methylation profiling

研究成果: 書貢獻/報告類型章節

2 引文 斯高帕斯(Scopus)

摘要

DNA methylation is an important regulatory step in gene expression. Knowledge of the alterations in DNA methylation at a whole genome scale improves our understanding of gene regulation and potential correlations with biological events or disease progression. Methylated DNA immunoprecipitation (MeDIP) uses an antibody that efficiently enriches methylated DNA fragments for downstream locus-specific or genome-wide analyses. MeDIP-on-Chip uses the MeDIP approach in combination with a tiling array for the investigation of genome-wide DNA methylation patterns (or DNA methylomics). The following protocol describes the application of MeDIP to the hybridization of DNA microarrays and data analysis.
原文英語
主出版物標題Cervical Cancer: Methods and Protocols
發行者Springer New York
頁面281-290
頁數10
ISBN(列印)9781493920136, 9781493920129
DOIs
出版狀態已發佈 - 十月 27 2014

    指紋

ASJC Scopus subject areas

  • Medicine(all)

引用此

Hsu, Y. W., Huang, R. L., & Lai, H. C. (2014). MeDIP-on-chip for methylation profiling. 於 Cervical Cancer: Methods and Protocols (頁 281-290). Springer New York. https://doi.org/10.1007/978-1-4939-2013-6_21