Medial prefrontal cortex and nucleus accumbens core are involved in retrieval of the methamphetamine-associated memory

Chih Yuan Chiang, Chianfang G. Cherng, Yu Ting Lai, Hsin Yi Fan, Jia Ying Chuang, Gour Shenq Kao, Wan Ting Chang, Lung Yu

研究成果: 雜誌貢獻文章

12 引文 (Scopus)

摘要

Immunohistochemical Fos staining has proven to be a method to identify the neurons that are activated by stimulation. Although methamphetamine (MA)-conditioned place preference (CPP) memory was long-lasting, how this memory was established and retrieved remained unknown. We used the vehicle- and MA-conditioned environment (including cues and context) to reactivate the MA-CPP memory in mice. In the limbic system, Fos-positive neurons were examined following retrieval of the MA-CPP memory. We demonstrated that the current conditioning procedure produced reliable MA-CPP performance. Moreover, enhanced Fos expressions were found in the medial prefrontal cortex and the core of the nucleus accumbens after reactivation of the MA-CPP memory. Furthermore, familiarity with the environmental cues/context was found to significantly enhance Fos expressions in dorsal striatum and dentate gyrus. Nucleus accumbens shell, basolateral or lateral amygdala, in this regard, did not seem to be involved in retrieval of the MA-CPP memory. These results, taken together, suggest that the medial prefrontal cortex and the core of the nucleus accumbens are anatomical substrates responsible for reactivation of the MA-CPP memory.
原文英語
頁(從 - 到)24-30
頁數7
期刊Behavioural Brain Research
197
發行號1
DOIs
出版狀態已發佈 - 一月 30 2009
對外發佈Yes

指紋

Methamphetamine
Nucleus Accumbens
Prefrontal Cortex
Cues
Neurons
Limbic System
Dentate Gyrus
Amygdala
Staining and Labeling

ASJC Scopus subject areas

  • Behavioral Neuroscience

引用此文

Medial prefrontal cortex and nucleus accumbens core are involved in retrieval of the methamphetamine-associated memory. / Chiang, Chih Yuan; Cherng, Chianfang G.; Lai, Yu Ting; Fan, Hsin Yi; Chuang, Jia Ying; Kao, Gour Shenq; Chang, Wan Ting; Yu, Lung.

於: Behavioural Brain Research, 卷 197, 編號 1, 30.01.2009, p. 24-30.

研究成果: 雜誌貢獻文章

Chiang, Chih Yuan ; Cherng, Chianfang G. ; Lai, Yu Ting ; Fan, Hsin Yi ; Chuang, Jia Ying ; Kao, Gour Shenq ; Chang, Wan Ting ; Yu, Lung. / Medial prefrontal cortex and nucleus accumbens core are involved in retrieval of the methamphetamine-associated memory. 於: Behavioural Brain Research. 2009 ; 卷 197, 編號 1. 頁 24-30.
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abstract = "Immunohistochemical Fos staining has proven to be a method to identify the neurons that are activated by stimulation. Although methamphetamine (MA)-conditioned place preference (CPP) memory was long-lasting, how this memory was established and retrieved remained unknown. We used the vehicle- and MA-conditioned environment (including cues and context) to reactivate the MA-CPP memory in mice. In the limbic system, Fos-positive neurons were examined following retrieval of the MA-CPP memory. We demonstrated that the current conditioning procedure produced reliable MA-CPP performance. Moreover, enhanced Fos expressions were found in the medial prefrontal cortex and the core of the nucleus accumbens after reactivation of the MA-CPP memory. Furthermore, familiarity with the environmental cues/context was found to significantly enhance Fos expressions in dorsal striatum and dentate gyrus. Nucleus accumbens shell, basolateral or lateral amygdala, in this regard, did not seem to be involved in retrieval of the MA-CPP memory. These results, taken together, suggest that the medial prefrontal cortex and the core of the nucleus accumbens are anatomical substrates responsible for reactivation of the MA-CPP memory.",
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AU - Fan, Hsin Yi

AU - Chuang, Jia Ying

AU - Kao, Gour Shenq

AU - Chang, Wan Ting

AU - Yu, Lung

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