Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins

S. L. Chang, Y. C. Chen, Y. J. Chen, W. Wangcharoen, S. H. Lee, C. I. Lin, S. A. Chen

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89 引文 斯高帕斯(Scopus)

摘要

Background: Atrial fibrillation is commonly associated with dilated pulmonary veins. Stretch has been shown to have mechano-electrical effects. Objective: To investigate whether stretch can increase the arrhythmogenic activity of the pulmonary veins. Methods: The transmembrane action potentials were recorded from rabbit pulmonary veins before and after stretch (100 and 300 mg). Gadolinium and streptomycin (stretch-activated ion channel blockers) were each perfused into the pulmonary veins under a 300-mg stretch. Results: Stretch (0, 100 and 300 mg) force dependently increased the incidence of spontaneous activity (22%, 48% and 83%; p

原文英語
頁(從 - 到)82-88
頁數7
期刊Heart
93
發行號1
DOIs
出版狀態已發佈 - 一月 2007

ASJC Scopus subject areas

  • 心臟病學與心血管醫學

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