Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins

S. L. Chang, Y. C. Chen, Y. J. Chen, W. Wangcharoen, S. H. Lee, C. I. Lin, S. A. Chen

研究成果: 雜誌貢獻文章

83 引文 斯高帕斯(Scopus)

摘要

Background: Atrial fibrillation is commonly associated with dilated pulmonary veins. Stretch has been shown to have mechano-electrical effects. Objective: To investigate whether stretch can increase the arrhythmogenic activity of the pulmonary veins. Methods: The transmembrane action potentials were recorded from rabbit pulmonary veins before and after stretch (100 and 300 mg). Gadolinium and streptomycin (stretch-activated ion channel blockers) were each perfused into the pulmonary veins under a 300-mg stretch. Results: Stretch (0, 100 and 300 mg) force dependently increased the incidence of spontaneous activity (22%, 48% and 83%; p

原文英語
頁(從 - 到)82-88
頁數7
期刊Heart
93
發行號1
DOIs
出版狀態已發佈 - 一月 2007

    指紋

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

引用此

Chang, S. L., Chen, Y. C., Chen, Y. J., Wangcharoen, W., Lee, S. H., Lin, C. I., & Chen, S. A. (2007). Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins. Heart, 93(1), 82-88. https://doi.org/10.1136/hrt.2006.089359