Mechanistic impact of outdoor air pollution on asthma and allergic diseases

Shau Ku Huang, Qingling Zhang, Zhiming Qiu, Kian Fan Chung

研究成果: 雜誌貢獻回顧型文獻同行評審

90 引文 斯高帕斯(Scopus)

摘要

Over the past decades, asthma and allergic diseases, such as allergic rhinitis and eczema, have become increasingly common, but the reason for this increased prevalence is still unclear. It has become apparent that genetic variation alone is not sufficient to account for the observed changes; rather, the changing environment, together with alterations in lifestyle and eating habits, are likely to have driven the increase in prevalence, and in some cases, severity of disease. This is particularly highlighted by recent awareness of, and concern about, the exposure to ubiquitous environmental pollutants, including chemicals with oxidant-generating capacities, and their impact on the human respiratory and immune systems. Indeed, several epidemiological studies have identified a variety of risk factors, including ambient pollutant gases and airborne particles, for the prevalence and the exacerbation of allergic diseases. However, the responsible pollutants remain unclear and the causal relationship has not been established. Recent studies of cellular and animal models have suggested several plausible mechanisms, with the most consistent observation being the direct effects of particle components on the generation of reactive oxygen species (ROS) and the resultant oxidative stress and inflammatory responses. This review attempts to highlight the experimental findings, with particular emphasis on several major mechanistic events initiated by exposure to particulate matters (PMs) in the exposure-disease relationship.

原文英語
頁(從 - 到)23-33
頁數11
期刊Journal of Thoracic Disease
7
發行號1
DOIs
出版狀態已發佈 - 一月 1 2015
對外發佈

ASJC Scopus subject areas

  • 肺和呼吸系統醫學

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