Mechanism of Taiwan Mingjian Oolong Tea to Inhibit Isoproterenol-Induced Hypertrophy and Apoptosis in Cardiomyoblasts

Yu Lan Yeh, Hsiang I. Tsai, Shiu Min Cheng, Peiying Pai, Tsung Jung Ho, Ray Jade Chen, Chao Hung Lai, Pei Jane Huang, V. Vijaya Padma, Chih Yang Huang

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)

摘要

This study investigates the cardio-protective effect of Nos. 1 and 5 extracts from Taiwan Mingjian Oolong Tea on H9c2 cardiomyoblast cells treated with isoproterenol (ISO). Treatment with Nos. 1 and 5 extracts increased cell viability and blocked apoptosis in ISO exposed H9c2 cells. Moreover, Nos. 1 and 5 extracts blocked hypertrophy markers like Gαs, calcineurin, NFATc3, and BNP, thereby increasing cell proliferation markers-PI3K and AKT in a dose dependent manner. In contrast, apoptotic proteins, such as caspase-3 and cytochrome c were decreased in H9c2 cells treated with Nos. 1 and 5 extracts. We confirmed that the protective effect of No. 1 extract was partially mediated through the expression of ERK and p38, however, the No. 5 extract showed a protective effect via the ERK, JNK, and p38 pathways. This evidence provides new insights into the pharmacological role and therapeutic mechanism of Taiwan Mingjian Oolong Tea in heart diseases.
原文英語
頁(從 - 到)77-86
頁數10
期刊American Journal of Chinese Medicine
44
發行號1
DOIs
出版狀態已發佈 - 二月 1 2016

    指紋

ASJC Scopus subject areas

  • Complementary and alternative medicine

引用此

Yeh, Y. L., Tsai, H. I., Cheng, S. M., Pai, P., Ho, T. J., Chen, R. J., Lai, C. H., Huang, P. J., Padma, V. V., & Huang, C. Y. (2016). Mechanism of Taiwan Mingjian Oolong Tea to Inhibit Isoproterenol-Induced Hypertrophy and Apoptosis in Cardiomyoblasts. American Journal of Chinese Medicine, 44(1), 77-86. https://doi.org/10.1142/S0192415X16500051