Mechanism of protection by zinc against mercuric chloride toxicity in rats: Effects of zinc and mercury on glutathionine metabolism

Hideki Fukino, Masami Hirai, Yu-Mei Hsueh, S. Moriyasu, Yasuhiro Yamane

研究成果: 雜誌貢獻文章

57 引文 (Scopus)

摘要

To investigate the mechanism by which zinc suppresses mercury toxicity, the effects of zinc and mercury on giutathione (GSH) metabolism in the rat kidney were studied. When the time course of GSH level in the rat kidney was examined at 2, 6, and 12 h after treatment of rats with both metals, an increase of GSH was found and was apparently related to the activation of some GSH-associated enzymes. In the kidney of rats treated with both metals, the response of the protective function involving GSH and GSH-associated enzymes depended on the magnitude of mercury toxicity but appeared to be independent of the zinc dosage. The administration of diethyl maleate (DEM), which depletes GSH, increased lipid peroxidation and mercury toxicity concomitantly with a decrease of GSH level in the kidney of rats treated with zinc and mercury. In conclusion, the data suggest that an increased GSH level in the kidney resulting from the activation of GSH-associated enzymes plays a role in the protective effect of zinc against mercury toxicity.
原文英語
頁(從 - 到)75-89
頁數15
期刊Journal of Toxicology and Environmental Health
19
發行號1
出版狀態已發佈 - 1986
對外發佈Yes

指紋

Mercuric Chloride
Mercury (metal)
Mercury
Metabolism
Toxicity
Zinc
Rats
Kidney
Enzymes
diethyl maleate
Chemical activation
Metals
Lipids
Lipid Peroxidation
Glutathione

ASJC Scopus subject areas

  • Toxicology
  • Pollution

引用此文

Mechanism of protection by zinc against mercuric chloride toxicity in rats : Effects of zinc and mercury on glutathionine metabolism. / Fukino, Hideki; Hirai, Masami; Hsueh, Yu-Mei; Moriyasu, S.; Yamane, Yasuhiro.

於: Journal of Toxicology and Environmental Health, 卷 19, 編號 1, 1986, p. 75-89.

研究成果: 雜誌貢獻文章

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abstract = "To investigate the mechanism by which zinc suppresses mercury toxicity, the effects of zinc and mercury on glutathione (GSH) metabolism in the rat kidney were studied. When the time course of GSH level in the rat kidney was examined at 2, 6, and 12 h after treatment of rats with both metals, an increase of GSH was found and was apparently related to the activation of some GSH-associated enzymes. In the kidney of rats treated with both metals, the response of the protective function involving GSH and GSH-associated enzymes depended on the magnitude of mercury toxicity but appeared to be independent of the zinc dosage. The administration of diethyl maleate (DEM), which depletes GSH, increased lipid peroxidation and mercury toxicity concomitantly with a decrease of GSH level in the kidney of rats treated with zinc and mercury. In conclusion, the data suggest that an increased GSH level in the kidney resulting from the activation of GSH-associated enzymes plays a role in the protective effect of zinc against mercury toxicity.",
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AU - Moriyasu, S.

AU - Yamane, Yasuhiro

PY - 1986

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N2 - To investigate the mechanism by which zinc suppresses mercury toxicity, the effects of zinc and mercury on glutathione (GSH) metabolism in the rat kidney were studied. When the time course of GSH level in the rat kidney was examined at 2, 6, and 12 h after treatment of rats with both metals, an increase of GSH was found and was apparently related to the activation of some GSH-associated enzymes. In the kidney of rats treated with both metals, the response of the protective function involving GSH and GSH-associated enzymes depended on the magnitude of mercury toxicity but appeared to be independent of the zinc dosage. The administration of diethyl maleate (DEM), which depletes GSH, increased lipid peroxidation and mercury toxicity concomitantly with a decrease of GSH level in the kidney of rats treated with zinc and mercury. In conclusion, the data suggest that an increased GSH level in the kidney resulting from the activation of GSH-associated enzymes plays a role in the protective effect of zinc against mercury toxicity.

AB - To investigate the mechanism by which zinc suppresses mercury toxicity, the effects of zinc and mercury on glutathione (GSH) metabolism in the rat kidney were studied. When the time course of GSH level in the rat kidney was examined at 2, 6, and 12 h after treatment of rats with both metals, an increase of GSH was found and was apparently related to the activation of some GSH-associated enzymes. In the kidney of rats treated with both metals, the response of the protective function involving GSH and GSH-associated enzymes depended on the magnitude of mercury toxicity but appeared to be independent of the zinc dosage. The administration of diethyl maleate (DEM), which depletes GSH, increased lipid peroxidation and mercury toxicity concomitantly with a decrease of GSH level in the kidney of rats treated with zinc and mercury. In conclusion, the data suggest that an increased GSH level in the kidney resulting from the activation of GSH-associated enzymes plays a role in the protective effect of zinc against mercury toxicity.

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