Measurement of the urinary lactate: creatinine ratio for the early identification of newborn infants at risk for hypoxic-ischemic encephalopathy

Chao Ching Huang, Shan Tair Wang, Ying Chao Chang, Kung Ping Lin, Pei Lin Wu

研究成果: 雜誌貢獻文章同行評審

96 引文 斯高帕斯(Scopus)

摘要

Background: Newborn infants with perinatal asphyxia are prone to the development of hypoxicischemic encephalopathy. There are no reliable methods for identifying infants at risk for this disorder. Methods: We measured the ratio of lactate to creatinine in urine by proton nuclear magnetic resonance spectroscopy within 6 hours and again 48 to 72 hours after birth in 58 normal infants and 40 infants with asphyxia. The results were correlated with the subsequent presence or absence of hypoxic-ischemic encephalopathy. Results: Hypoxic-ischemic encephalopathy did not develop in any of the normal newborns but did develop in 16 of the 40 newborns with asphyxia. Within six hours after birth, the mean (±SD) ratio of urinary lactate to creatinine was 16.76±27.38 in the infants who subsequently had hypoxic-ischemic encephalopathy, as compared with 0.09±0.02 in the normal infants (P

原文英語
頁(從 - 到)328-335
頁數8
期刊New England Journal of Medicine
341
發行號5
DOIs
出版狀態已發佈 - 七月 29 1999
對外發佈Yes

ASJC Scopus subject areas

  • Medicine(all)

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