Measurement of gp130 cytokines - Oncostatin M and IL-6 in gingival crevicular fluid of patients with chronic periodontitis

Shih Jung Lin, Yung Li Chen, Mark Yen Bin Kuo, Chuan Li Li, Hsein Kun Lu

研究成果: 雜誌貢獻文章同行評審

63 引文 斯高帕斯(Scopus)


Several proinflammatory cytokines can induce periodontal tissue destruction and are thought to be useful indicators or diagnostic markers for periodontitis. Here, we aimed to investigate whether oncostatin M (OSM) was present in gingival crevicular fluid (GCF) and to clarify the correlation of GCF OSM and interleukin-6 (IL-6) levels with the severity of periodontitis. Sixty-two sites in 14 patients were divided into 4 groups based on probing depth (PD) and bleeding on probing (BOP). GCF was collected using paper strips from clinically health sites (PD ≤ 3 mm, CAL: 1-3 mm, without BOP, n = 31), mildly diseased sites (PD ≤ 3 mm, CAL: 3-5 mm, with BOP, n = 11), moderately diseased sites (PD = 4-6 mm, CAL: 5-8 mm, with BOP, n = 11), and severely diseased sites (PD > 6 mm, CAL: 8-12 mm, with BOP, n = 9). IL-6 and OSM in GCF were quantified by enzyme-linked immunosorbent assay and are expressed as concentrations (pg/ml) and total amounts (pg/site). Correlations of OSM and IL-6 levels with the severity of periodontitis in all groups were determined using Spearman rank correlation (rs). Our results showed that OSM and IL-6 were detected in most GCF samples. The total amounts of OSM and IL-6 were significantly positive correlated with severity of diseased sites (OSM: r s = 0.526, p <0.01; IL-6: rs = 0.729, p <0.01). No correlations of OSM or IL-6 concentration in GCF were found with disease severity. OSM and IL-6 levels in GCF were positively correlated to each other when expressed as either concentrations or total amounts (concentrations: r = 0.485, p <0.01; total amounts r = 0.490, p <0.01). In conclusion, our findings suggest that IL-6 and OSM may play a role in modulating the inflammatory cascade of chronic periodontitis.
頁(從 - 到)160-167
出版狀態已發佈 - 5月 21 2005

ASJC Scopus subject areas

  • 內分泌
  • 分子生物學
  • 免疫學
  • 免疫學和過敏


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