摘要

The physiological changes in endometriosis involving multiple steps of matrix remodeling include abnormal tissue growth, invasion, and adhesion formation. Endometriosis-associated abnormal matrix remodeling is affected by several molecular factors including proteolytic enzymes and their inhibitors, which mediate tissue turnover throughout the reproductive tract to maintain the integrity of the endometrium, and ovarian steroids, which normally regulate reconstruction and breakdown of endometrium in the menstrual cycle. In addition, various growth factors, such as platelet-derived growth factor, transform growth factor β, and epidermal growth factor, direct modulation of growth, activation, and chemotaxis which may facilitate endometrial cell adhesion onto the peritoneal mesothelium during the development of endometriosis. Furthermore, cell adhesion molecules are believed to be critically involved in most cellular-level processes including cellular differentiation, motility, and attachment with the extracellular matrix. The present review focuses on the abnormal matrix remodeling process and its possible regulatory mechanism in association with endometriosis development. As a greater understanding of the cause of endometriosis is achieved, better treatment of the disease and its prevention become possible.
原文英語
頁(從 - 到)93-99
頁數7
期刊Reproductive Medicine and Biology
4
發行號2
DOIs
出版狀態已發佈 - 六月 2005

指紋

Endometriosis
Endometrium
Intercellular Signaling Peptides and Proteins
Platelet-Derived Growth Factor
Cell Adhesion Molecules
Enzyme Inhibitors
Chemotaxis
Menstrual Cycle
Growth
Epidermal Growth Factor
Cell Adhesion
Extracellular Matrix
Peptide Hydrolases
Epithelium
Steroids

ASJC Scopus subject areas

  • Reproductive Medicine
  • Physiology

引用此文

Matrix remodeling and endometriosis. / Yang, Wei Chung Vivian; Au, Heng Kien; Chang, Ching Wen; Chen, Huei Wen; Chen, Pi Hua; Chen, Chieh Cheng; Tang, Yun Long; Wang, I. Te; Tzeng, Chii Ruey.

於: Reproductive Medicine and Biology, 卷 4, 編號 2, 06.2005, p. 93-99.

研究成果: 雜誌貢獻文章

Yang, WCV, Au, HK, Chang, CW, Chen, HW, Chen, PH, Chen, CC, Tang, YL, Wang, IT & Tzeng, CR 2005, 'Matrix remodeling and endometriosis', Reproductive Medicine and Biology, 卷 4, 編號 2, 頁 93-99. https://doi.org/10.1111/j.1447-0578.2005.00098.x
Yang, Wei Chung Vivian ; Au, Heng Kien ; Chang, Ching Wen ; Chen, Huei Wen ; Chen, Pi Hua ; Chen, Chieh Cheng ; Tang, Yun Long ; Wang, I. Te ; Tzeng, Chii Ruey. / Matrix remodeling and endometriosis. 於: Reproductive Medicine and Biology. 2005 ; 卷 4, 編號 2. 頁 93-99.
@article{62ee33c12518497493e19f746253f564,
title = "Matrix remodeling and endometriosis",
abstract = "The physiological changes in endometriosis involving multiple steps of matrix remodeling include abnormal tissue growth, invasion, and adhesion formation. Endometriosis-associated abnormal matrix remodeling is affected by several molecular factors including proteolytic enzymes and their inhibitors, which mediate tissue turnover throughout the reproductive tract to maintain the integrity of the endometrium, and ovarian steroids, which normally regulate reconstruction and breakdown of endometrium in the menstrual cycle. In addition, various growth factors, such as platelet-derived growth factor, transform growth factor β, and epidermal growth factor, direct modulation of growth, activation, and chemotaxis which may facilitate endometrial cell adhesion onto the peritoneal mesothelium during the development of endometriosis. Furthermore, cell adhesion molecules are believed to be critically involved in most cellular-level processes including cellular differentiation, motility, and attachment with the extracellular matrix. The present review focuses on the abnormal matrix remodeling process and its possible regulatory mechanism in association with endometriosis development. As a greater understanding of the cause of endometriosis is achieved, better treatment of the disease and its prevention become possible.",
keywords = "Endometriosis, Extracellular matrix, Matrix metalloprotease, Matrix remodeling, Tissue inhibitors for matrix metalloprotease",
author = "Yang, {Wei Chung Vivian} and Au, {Heng Kien} and Chang, {Ching Wen} and Chen, {Huei Wen} and Chen, {Pi Hua} and Chen, {Chieh Cheng} and Tang, {Yun Long} and Wang, {I. Te} and Tzeng, {Chii Ruey}",
year = "2005",
month = "6",
doi = "10.1111/j.1447-0578.2005.00098.x",
language = "English",
volume = "4",
pages = "93--99",
journal = "Reproductive Medicine and Biology",
issn = "1445-5781",
publisher = "Springer Japan",
number = "2",

}

TY - JOUR

T1 - Matrix remodeling and endometriosis

AU - Yang, Wei Chung Vivian

AU - Au, Heng Kien

AU - Chang, Ching Wen

AU - Chen, Huei Wen

AU - Chen, Pi Hua

AU - Chen, Chieh Cheng

AU - Tang, Yun Long

AU - Wang, I. Te

AU - Tzeng, Chii Ruey

PY - 2005/6

Y1 - 2005/6

N2 - The physiological changes in endometriosis involving multiple steps of matrix remodeling include abnormal tissue growth, invasion, and adhesion formation. Endometriosis-associated abnormal matrix remodeling is affected by several molecular factors including proteolytic enzymes and their inhibitors, which mediate tissue turnover throughout the reproductive tract to maintain the integrity of the endometrium, and ovarian steroids, which normally regulate reconstruction and breakdown of endometrium in the menstrual cycle. In addition, various growth factors, such as platelet-derived growth factor, transform growth factor β, and epidermal growth factor, direct modulation of growth, activation, and chemotaxis which may facilitate endometrial cell adhesion onto the peritoneal mesothelium during the development of endometriosis. Furthermore, cell adhesion molecules are believed to be critically involved in most cellular-level processes including cellular differentiation, motility, and attachment with the extracellular matrix. The present review focuses on the abnormal matrix remodeling process and its possible regulatory mechanism in association with endometriosis development. As a greater understanding of the cause of endometriosis is achieved, better treatment of the disease and its prevention become possible.

AB - The physiological changes in endometriosis involving multiple steps of matrix remodeling include abnormal tissue growth, invasion, and adhesion formation. Endometriosis-associated abnormal matrix remodeling is affected by several molecular factors including proteolytic enzymes and their inhibitors, which mediate tissue turnover throughout the reproductive tract to maintain the integrity of the endometrium, and ovarian steroids, which normally regulate reconstruction and breakdown of endometrium in the menstrual cycle. In addition, various growth factors, such as platelet-derived growth factor, transform growth factor β, and epidermal growth factor, direct modulation of growth, activation, and chemotaxis which may facilitate endometrial cell adhesion onto the peritoneal mesothelium during the development of endometriosis. Furthermore, cell adhesion molecules are believed to be critically involved in most cellular-level processes including cellular differentiation, motility, and attachment with the extracellular matrix. The present review focuses on the abnormal matrix remodeling process and its possible regulatory mechanism in association with endometriosis development. As a greater understanding of the cause of endometriosis is achieved, better treatment of the disease and its prevention become possible.

KW - Endometriosis

KW - Extracellular matrix

KW - Matrix metalloprotease

KW - Matrix remodeling

KW - Tissue inhibitors for matrix metalloprotease

UR - http://www.scopus.com/inward/record.url?scp=21344443491&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=21344443491&partnerID=8YFLogxK

U2 - 10.1111/j.1447-0578.2005.00098.x

DO - 10.1111/j.1447-0578.2005.00098.x

M3 - Article

AN - SCOPUS:21344443491

VL - 4

SP - 93

EP - 99

JO - Reproductive Medicine and Biology

JF - Reproductive Medicine and Biology

SN - 1445-5781

IS - 2

ER -