Matrix metalloproteinases (MMP) 1 and MMP10 but not MMP12 are potential oral cancer markers

Ching Yu Yen, Chung Ho Chen, Chao Hsiang Chang, Hung Fu Tseng, Shyun Yeu Liu, Li Yeh Chuang, Cheng Hao Wen, Hsueh Wei Chang

研究成果: 雜誌貢獻文章同行評審

54 引文 斯高帕斯(Scopus)

摘要

The aim of this study was to investigate the mRNA performance of matrix metalloproteinases (MMP) 1, MMP10 and MMP12 as oral cancer markers. With gingiva as the control, the areas under the receiver- operating characteristic curves (AUCs) of the relative gene expressions for MMP1, MMP10 and MMP12 were 0.715, 0.727 and 0.513, respectively. With the margins or neck platysma muscles as controls, the AUCs of MMP1, MMP10 and MMP12 were 0.746 vs 0.626, 0.712 vs 0.683 and 0.697 vs 0.630, respectively. MMP10 displayed the best sensitivity for oral cancer detection with any controls. MMP1 and MMP10 were suitable markers for cancer detection with gingiva and margin as controls. Using neck tissue as the control, only MMP10 was suitable for cancer detection. With margin and neck controls, there were no significant differences for MMP1, MMP10 and MMP12 in different stages, invasion and locations or different habits. Therefore, MMP1 and MMP10 but not MMP12 are potential oral cancer markers.
原文英語
頁(從 - 到)244-249
頁數6
期刊Biomarkers
14
發行號4
DOIs
出版狀態已發佈 - 六月 2009

ASJC Scopus subject areas

  • 生物化學
  • 臨床生物化學
  • 健康、毒理學和誘變
  • 醫藥 (全部)

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