Matrix metalloproteinase-9 in cerebral-amyloid-angiopathy-related hemorrhage

Jin Moo Lee, Kejie Yin, Idar Hsin, Shawei Chen, John D. Fryer, David M. Holtzman, Chung Y. Hsu, Jian Xu

研究成果: 雜誌貢獻文章同行評審

52 引文 斯高帕斯(Scopus)


Spontaneous intracerebral hemorrhage (ICH) is one of the most recognized complications of cerebral amyloid angiopathy (CAA), but little is known about the molecular pathogenesis of this life-threatening complication. In this review, we present preliminary evidence which suggests that the extracellular-matrix-degrading protease, matrix metalloproteinase-9 (MMP-9), may play a role in the development of spontaneous ICH resulting from CAA. The amyloid-beta peptide (Aβ) induced the synthesis, cellular release, and activation of MMP-9 in murine cerebral endothelial cells (CECs), resulting in increased extracellular matrix (ECM) degradation. Furthermore, in a mouse model of CAA (APPsw transgenic mice), MMP-9 immunoreactivity was observed in amyloid-laden cerebral vessels in aged APPsw mice but not in young APPsw or aged wild-type mice. More extensive MMP-9 immunostaining was present in amyloid-laden vessels with evidence of microhemorrhage. These results suggest that increased vascular MMP-9 expression, stimulated by Aβ, may play a role in the pathogenesis of spontaneous intracerebral hemorrhage (ICH) in patients with CAA.
頁(從 - 到)249-254
期刊Journal of the Neurological Sciences
出版狀態已發佈 - 3月 15 2005

ASJC Scopus subject areas

  • 老化
  • 神經病學(臨床)
  • 手術
  • 發展神經科學
  • 神經內科
  • 神經科學 (全部)


深入研究「Matrix metalloproteinase-9 in cerebral-amyloid-angiopathy-related hemorrhage」主題。共同形成了獨特的指紋。