Matrix metalloproteinase-2 as a target for head and neck cancer therapy

Ming Hsien Chien, Chiao Wen Lin, Chao Wen Cheng, Yu-Ching Wen, Shun Fa Yang

研究成果: 雜誌貢獻文章

51 引文 (Scopus)

摘要

Introduction: Matrix metalloproteinase (MMP)-2 is a zinc-dependent proteinase that is capable of cleaving all extracellular matrix (ECM) substrates. Degradation of the matrix is a key event in the progression, invasion, and metastasis of potentially malignant and malignant lesions of the head and neck. Therefore, blocking MMP-2 expression or activity may present a promising strategy for anticancer treatment. Areas covered: Current understanding of the molecular mechanisms that govern MMP-2 regulation and its tumorigenic effects, and that are involved in the initiation and progression of head and neck cancers, in particular the emerging role of MMP-2 in cell migration, which is a prerequisite for tumor metastasis. MMP-2 gene polymorphisms, cellular substrates, and interacting proteins are summarized. The current state of drugs that target this enzyme, either alone or in combination with other targeted agents are also discussed. Expert opinion: MMP-2 has long been a drug target. The current status of MMP-2 inhibitors as anticancer agents and their failure in the clinic is discussed in light of new data on the MMP-2s role as a cell surface transducer-data that may lead to the design and development of novel, MMP-2-targeting inhibitors.
原文英語
頁(從 - 到)203-216
頁數14
期刊Expert Opinion on Therapeutic Targets
17
發行號2
DOIs
出版狀態已發佈 - 二月 2013

指紋

Matrix Metalloproteinase 2
Head and Neck Neoplasms
Therapeutics
Neoplasm Metastasis
Matrix Metalloproteinase Inhibitors
Expert Testimony
Substrates
Polymorphism
Transducers
Matrix Metalloproteinases
Pharmaceutical Preparations
Antineoplastic Agents
Cell Movement
Extracellular Matrix
Zinc
Tumors
Peptide Hydrolases
Neck
Genes
Head

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

引用此文

Matrix metalloproteinase-2 as a target for head and neck cancer therapy. / Chien, Ming Hsien; Lin, Chiao Wen; Cheng, Chao Wen; Wen, Yu-Ching; Yang, Shun Fa.

於: Expert Opinion on Therapeutic Targets, 卷 17, 編號 2, 02.2013, p. 203-216.

研究成果: 雜誌貢獻文章

@article{aa28f1beaa064b66b7cdd0604aab079a,
title = "Matrix metalloproteinase-2 as a target for head and neck cancer therapy",
abstract = "Introduction: Matrix metalloproteinase (MMP)-2 is a zinc-dependent proteinase that is capable of cleaving all extracellular matrix (ECM) substrates. Degradation of the matrix is a key event in the progression, invasion, and metastasis of potentially malignant and malignant lesions of the head and neck. Therefore, blocking MMP-2 expression or activity may present a promising strategy for anticancer treatment. Areas covered: Current understanding of the molecular mechanisms that govern MMP-2 regulation and its tumorigenic effects, and that are involved in the initiation and progression of head and neck cancers, in particular the emerging role of MMP-2 in cell migration, which is a prerequisite for tumor metastasis. MMP-2 gene polymorphisms, cellular substrates, and interacting proteins are summarized. The current state of drugs that target this enzyme, either alone or in combination with other targeted agents are also discussed. Expert opinion: MMP-2 has long been a drug target. The current status of MMP-2 inhibitors as anticancer agents and their failure in the clinic is discussed in light of new data on the MMP-2s role as a cell surface transducer-data that may lead to the design and development of novel, MMP-2-targeting inhibitors.",
keywords = "Head and neck cancer, MMP-2, Molecular target, Signaling networks",
author = "Chien, {Ming Hsien} and Lin, {Chiao Wen} and Cheng, {Chao Wen} and Yu-Ching Wen and Yang, {Shun Fa}",
year = "2013",
month = "2",
doi = "10.1517/14728222.2013.740012",
language = "English",
volume = "17",
pages = "203--216",
journal = "Expert Opinion on Therapeutic Targets",
issn = "1472-8222",
publisher = "Informa Healthcare",
number = "2",

}

TY - JOUR

T1 - Matrix metalloproteinase-2 as a target for head and neck cancer therapy

AU - Chien, Ming Hsien

AU - Lin, Chiao Wen

AU - Cheng, Chao Wen

AU - Wen, Yu-Ching

AU - Yang, Shun Fa

PY - 2013/2

Y1 - 2013/2

N2 - Introduction: Matrix metalloproteinase (MMP)-2 is a zinc-dependent proteinase that is capable of cleaving all extracellular matrix (ECM) substrates. Degradation of the matrix is a key event in the progression, invasion, and metastasis of potentially malignant and malignant lesions of the head and neck. Therefore, blocking MMP-2 expression or activity may present a promising strategy for anticancer treatment. Areas covered: Current understanding of the molecular mechanisms that govern MMP-2 regulation and its tumorigenic effects, and that are involved in the initiation and progression of head and neck cancers, in particular the emerging role of MMP-2 in cell migration, which is a prerequisite for tumor metastasis. MMP-2 gene polymorphisms, cellular substrates, and interacting proteins are summarized. The current state of drugs that target this enzyme, either alone or in combination with other targeted agents are also discussed. Expert opinion: MMP-2 has long been a drug target. The current status of MMP-2 inhibitors as anticancer agents and their failure in the clinic is discussed in light of new data on the MMP-2s role as a cell surface transducer-data that may lead to the design and development of novel, MMP-2-targeting inhibitors.

AB - Introduction: Matrix metalloproteinase (MMP)-2 is a zinc-dependent proteinase that is capable of cleaving all extracellular matrix (ECM) substrates. Degradation of the matrix is a key event in the progression, invasion, and metastasis of potentially malignant and malignant lesions of the head and neck. Therefore, blocking MMP-2 expression or activity may present a promising strategy for anticancer treatment. Areas covered: Current understanding of the molecular mechanisms that govern MMP-2 regulation and its tumorigenic effects, and that are involved in the initiation and progression of head and neck cancers, in particular the emerging role of MMP-2 in cell migration, which is a prerequisite for tumor metastasis. MMP-2 gene polymorphisms, cellular substrates, and interacting proteins are summarized. The current state of drugs that target this enzyme, either alone or in combination with other targeted agents are also discussed. Expert opinion: MMP-2 has long been a drug target. The current status of MMP-2 inhibitors as anticancer agents and their failure in the clinic is discussed in light of new data on the MMP-2s role as a cell surface transducer-data that may lead to the design and development of novel, MMP-2-targeting inhibitors.

KW - Head and neck cancer

KW - MMP-2

KW - Molecular target

KW - Signaling networks

UR - http://www.scopus.com/inward/record.url?scp=84872240151&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872240151&partnerID=8YFLogxK

U2 - 10.1517/14728222.2013.740012

DO - 10.1517/14728222.2013.740012

M3 - Article

C2 - 23252422

AN - SCOPUS:84872240151

VL - 17

SP - 203

EP - 216

JO - Expert Opinion on Therapeutic Targets

JF - Expert Opinion on Therapeutic Targets

SN - 1472-8222

IS - 2

ER -