Maternal serum C-reactive protein level does not change significantly after fetal reduction: It could be used as an indicator of chorioamnionitis

Shee Uan Chen, Tsang Ming Ko, Hsiao Lin Hwa, Pei Jen Lu, Hong Nerng Ho, Yu Shih Yang

研究成果: 雜誌貢獻文章

5 引文 (Scopus)

摘要

Purpose: This study was aimed at investigating the diagnostic value of maternal serum C-reactive protein (CRP) in the recognition of chorioamnionitis in patients undergoing fetal reduction. Methods: Seventy-one gravidas with high-order multifetal pregnancies, including 46 with triplets, 18 with quadruplets, and 7 with quintuplets, who underwent transabdominal fetal reduction to twins during the 10th-14th gestational week were recruited. The subjects were followed up clinically and ultrasonographically 1 week and 1 month after fetal reduction for signs of infection, premature uterine contraction, and premature rupture of the membranes. CRP levels were measured prior to fetal reduction and at follow-up examinations, and were compared. Results: Among the 71 mothers, 65 (92%) were normal after fetal reduction. The CRP levels were not significantly different prior to the procedure (0.27 ± 0.26 mg/dL), and 1 week (0.23 ± 0.24 mg/dL) and 1 month (0.24 ± 0.20 mg/dL) later. There was no correlation between the number of fetuses reduced and the CRP levels. Six (8%) experienced leakage of amniotic fluid after fetal reduction. Three patients had normal CRP levels at that time and at the following tests. The pregnancies continued smoothly after conservative treatment. The other three patients had elevated CRP levels when leakage of amniotic fluid occurred. Fever and uterine irritability developed subsequently despite parenteral antibiotics and tocolytic therapy. Daily checks showed increasing CRP levels. The pregnancies were aborted, and the histology of the placental membranes revealed chorioamnionitis with infiltration of acute inflammatory cells. Conclusions: The absorption of inactive gestational tissue after fetal reduction did not affect CRP levels. CRP may be used as a marker of intrauterine infection after fetal reduction.
原文英語
頁(從 - 到)336-340
頁數5
期刊Journal of Assisted Reproduction and Genetics
18
發行號6
DOIs
出版狀態已發佈 - 八月 2 2001
對外發佈Yes

指紋

Multifetal Pregnancy Reduction
Chorioamnionitis
C-Reactive Protein
Blood Proteins
Mothers
Amniotic Fluid
Pregnancy
Quintuplets
Tocolysis
Uterine Contraction
Membranes
Infection
Rupture
Histology
Fetus
Fever
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Reproductive Medicine
  • Genetics
  • Obstetrics and Gynaecology
  • Developmental Biology
  • Genetics(clinical)

引用此文

Maternal serum C-reactive protein level does not change significantly after fetal reduction : It could be used as an indicator of chorioamnionitis. / Chen, Shee Uan; Ko, Tsang Ming; Hwa, Hsiao Lin; Lu, Pei Jen; Ho, Hong Nerng; Yang, Yu Shih.

於: Journal of Assisted Reproduction and Genetics, 卷 18, 編號 6, 02.08.2001, p. 336-340.

研究成果: 雜誌貢獻文章

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title = "Maternal serum C-reactive protein level does not change significantly after fetal reduction: It could be used as an indicator of chorioamnionitis",
abstract = "Purpose: This study was aimed at investigating the diagnostic value of maternal serum C-reactive protein (CRP) in the recognition of chorioamnionitis in patients undergoing fetal reduction. Methods: Seventy-one gravidas with high-order multifetal pregnancies, including 46 with triplets, 18 with quadruplets, and 7 with quintuplets, who underwent transabdominal fetal reduction to twins during the 10th-14th gestational week were recruited. The subjects were followed up clinically and ultrasonographically 1 week and 1 month after fetal reduction for signs of infection, premature uterine contraction, and premature rupture of the membranes. CRP levels were measured prior to fetal reduction and at follow-up examinations, and were compared. Results: Among the 71 mothers, 65 (92{\%}) were normal after fetal reduction. The CRP levels were not significantly different prior to the procedure (0.27 ± 0.26 mg/dL), and 1 week (0.23 ± 0.24 mg/dL) and 1 month (0.24 ± 0.20 mg/dL) later. There was no correlation between the number of fetuses reduced and the CRP levels. Six (8{\%}) experienced leakage of amniotic fluid after fetal reduction. Three patients had normal CRP levels at that time and at the following tests. The pregnancies continued smoothly after conservative treatment. The other three patients had elevated CRP levels when leakage of amniotic fluid occurred. Fever and uterine irritability developed subsequently despite parenteral antibiotics and tocolytic therapy. Daily checks showed increasing CRP levels. The pregnancies were aborted, and the histology of the placental membranes revealed chorioamnionitis with infiltration of acute inflammatory cells. Conclusions: The absorption of inactive gestational tissue after fetal reduction did not affect CRP levels. CRP may be used as a marker of intrauterine infection after fetal reduction.",
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T1 - Maternal serum C-reactive protein level does not change significantly after fetal reduction

T2 - It could be used as an indicator of chorioamnionitis

AU - Chen, Shee Uan

AU - Ko, Tsang Ming

AU - Hwa, Hsiao Lin

AU - Lu, Pei Jen

AU - Ho, Hong Nerng

AU - Yang, Yu Shih

PY - 2001/8/2

Y1 - 2001/8/2

N2 - Purpose: This study was aimed at investigating the diagnostic value of maternal serum C-reactive protein (CRP) in the recognition of chorioamnionitis in patients undergoing fetal reduction. Methods: Seventy-one gravidas with high-order multifetal pregnancies, including 46 with triplets, 18 with quadruplets, and 7 with quintuplets, who underwent transabdominal fetal reduction to twins during the 10th-14th gestational week were recruited. The subjects were followed up clinically and ultrasonographically 1 week and 1 month after fetal reduction for signs of infection, premature uterine contraction, and premature rupture of the membranes. CRP levels were measured prior to fetal reduction and at follow-up examinations, and were compared. Results: Among the 71 mothers, 65 (92%) were normal after fetal reduction. The CRP levels were not significantly different prior to the procedure (0.27 ± 0.26 mg/dL), and 1 week (0.23 ± 0.24 mg/dL) and 1 month (0.24 ± 0.20 mg/dL) later. There was no correlation between the number of fetuses reduced and the CRP levels. Six (8%) experienced leakage of amniotic fluid after fetal reduction. Three patients had normal CRP levels at that time and at the following tests. The pregnancies continued smoothly after conservative treatment. The other three patients had elevated CRP levels when leakage of amniotic fluid occurred. Fever and uterine irritability developed subsequently despite parenteral antibiotics and tocolytic therapy. Daily checks showed increasing CRP levels. The pregnancies were aborted, and the histology of the placental membranes revealed chorioamnionitis with infiltration of acute inflammatory cells. Conclusions: The absorption of inactive gestational tissue after fetal reduction did not affect CRP levels. CRP may be used as a marker of intrauterine infection after fetal reduction.

AB - Purpose: This study was aimed at investigating the diagnostic value of maternal serum C-reactive protein (CRP) in the recognition of chorioamnionitis in patients undergoing fetal reduction. Methods: Seventy-one gravidas with high-order multifetal pregnancies, including 46 with triplets, 18 with quadruplets, and 7 with quintuplets, who underwent transabdominal fetal reduction to twins during the 10th-14th gestational week were recruited. The subjects were followed up clinically and ultrasonographically 1 week and 1 month after fetal reduction for signs of infection, premature uterine contraction, and premature rupture of the membranes. CRP levels were measured prior to fetal reduction and at follow-up examinations, and were compared. Results: Among the 71 mothers, 65 (92%) were normal after fetal reduction. The CRP levels were not significantly different prior to the procedure (0.27 ± 0.26 mg/dL), and 1 week (0.23 ± 0.24 mg/dL) and 1 month (0.24 ± 0.20 mg/dL) later. There was no correlation between the number of fetuses reduced and the CRP levels. Six (8%) experienced leakage of amniotic fluid after fetal reduction. Three patients had normal CRP levels at that time and at the following tests. The pregnancies continued smoothly after conservative treatment. The other three patients had elevated CRP levels when leakage of amniotic fluid occurred. Fever and uterine irritability developed subsequently despite parenteral antibiotics and tocolytic therapy. Daily checks showed increasing CRP levels. The pregnancies were aborted, and the histology of the placental membranes revealed chorioamnionitis with infiltration of acute inflammatory cells. Conclusions: The absorption of inactive gestational tissue after fetal reduction did not affect CRP levels. CRP may be used as a marker of intrauterine infection after fetal reduction.

KW - C-reactive protein

KW - Chorioamnionitis

KW - Fetal reduction

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