Maternal nicotine exposure during gestation and lactation induces cardiac remodeling in rat offspring

研究成果: 雜誌貢獻文章同行評審

15 引文 斯高帕斯(Scopus)

摘要

The aim of this study was to evaluate the effects of maternal nicotine exposure on heart morphology and fibrosis in rat offspring. Nicotine was administered to pregnant Sprague-Dawley rats by using a subcutaneous osmotic mini-pump at a dose of 6. mg/kg/day from Gestational Days 7-21 or Gestational Day 7 to Postnatal Day 14. A control group received an equal volume of saline by the same route as nicotine. Rats born to prenatal nicotine-treated dams exhibited significantly greater cell width of cardiomyocytes, fewer cardiomyocyte nuclei number, higher β-myosin heavy chain and transforming growth factor (TGF-β1) expression, and higher collagen deposition in heart compared with rats born to normal saline-treated dams on Postnatal Days 7 and 21. Postnatal nicotine exposure further enhances these effects. We conclude that TGF-β1 may be involved in the pathogenesis of cardiac remodeling induced by maternal nicotine exposure during gestation and lactation in rat offspring.
原文英語
頁(從 - 到)4-10
頁數7
期刊Reproductive Toxicology
50
DOIs
出版狀態已發佈 - 12月 1 2014

ASJC Scopus subject areas

  • 毒理學
  • 醫藥 (全部)

指紋

深入研究「Maternal nicotine exposure during gestation and lactation induces cardiac remodeling in rat offspring」主題。共同形成了獨特的指紋。

引用此