Markers for efficacy of mammalian target of rapamycin inhibitor

Yu Min Liao, Alex Sy, Yun Yen

研究成果: 雜誌貢獻文章同行評審

6 引文 斯高帕斯(Scopus)

摘要

Mammalian target of rapamycin (mTOR), an important sensor for growth factors, nutritional deprivation and other stresses in controling translation, plays a critical role in tumorigenesis. Several rapalogs exhibited antitumor activity clinically, with a modest average response rate, while a small subset of patients exhibited significantly greater clinical benefits. A better understanding of cellular mechanisms and the results of clinical studies can help identify an optimal biomarker to predict the efficacy of mTOR inhibitors. We discuss these potential markers in terms of selection of candidates, baseline expression, pathway inhibition and source of targeted protein.
原文英語
頁(從 - 到)4235-4244
頁數10
期刊Anticancer Research
32
發行號10
出版狀態已發佈 - 十月 2012

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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