Markedly elevated plasma myeloperoxidase protein in patients with pelvic inflammatory disease who have A allele myeloperoxidase gene polymorphism

Shun An Lee, Po Hui Wang, Hui Ling Chiou, Ming Chin Chou, Hsiu Ting Tsai, Shun Fa Yang

研究成果: 雜誌貢獻文章

9 引文 (Scopus)

摘要

Objective: To compared the plasma levels and the genetic polymorphism of myeloperoxidase in patients with pelvic inflammatory disease (PID) and healthy controls. Design: A random consecutive study. Setting: University hospital. Patient(s): Forty-four women who were diagnosed with PID. Intervention(s): Collected blood specimens of patients before and after they received treatment. Main Outcome Measure(s): ELISA and polymerase chain reaction-restriction fragment length polymorphism were respectively used to measure the plasma levels and genetic polymorphism of myeloperoxidase. Result(s): We found the plasma level of myeloperoxidase was elevated in PID patients compared with that in normal controls and decreased significantly compared with that in the same patients after they received treatment. PID patients with myeloperoxidase G/A alleles significantly tended to have elevated plasma concentration of myeloperoxidase, whereas PID patients with G/G homozygous alleles did not. Conclusion(s): Elevated expression of myeloperoxidase may be involved in the pathogenesis of PID and could be useful for the diagnosis of PID. Furthermore, G/A alleles of myeloperoxidase may contribute to such elevation in PID patients.

原文英語
頁(從 - 到)1260-1266
頁數7
期刊Fertility and Sterility
93
發行號4
DOIs
出版狀態已發佈 - 三月 1 2010
對外發佈Yes

指紋

Pelvic Inflammatory Disease
Peroxidase
Blood Proteins
Inpatients
Alleles
Genes
Genetic Polymorphisms
Restriction Fragment Length Polymorphisms
Enzyme-Linked Immunosorbent Assay
Outcome Assessment (Health Care)
Polymerase Chain Reaction
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

引用此文

Markedly elevated plasma myeloperoxidase protein in patients with pelvic inflammatory disease who have A allele myeloperoxidase gene polymorphism. / Lee, Shun An; Wang, Po Hui; Chiou, Hui Ling; Chou, Ming Chin; Tsai, Hsiu Ting; Yang, Shun Fa.

於: Fertility and Sterility, 卷 93, 編號 4, 01.03.2010, p. 1260-1266.

研究成果: 雜誌貢獻文章

Lee, Shun An ; Wang, Po Hui ; Chiou, Hui Ling ; Chou, Ming Chin ; Tsai, Hsiu Ting ; Yang, Shun Fa. / Markedly elevated plasma myeloperoxidase protein in patients with pelvic inflammatory disease who have A allele myeloperoxidase gene polymorphism. 於: Fertility and Sterility. 2010 ; 卷 93, 編號 4. 頁 1260-1266.
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abstract = "Objective: To compared the plasma levels and the genetic polymorphism of myeloperoxidase in patients with pelvic inflammatory disease (PID) and healthy controls. Design: A random consecutive study. Setting: University hospital. Patient(s): Forty-four women who were diagnosed with PID. Intervention(s): Collected blood specimens of patients before and after they received treatment. Main Outcome Measure(s): ELISA and polymerase chain reaction-restriction fragment length polymorphism were respectively used to measure the plasma levels and genetic polymorphism of myeloperoxidase. Result(s): We found the plasma level of myeloperoxidase was elevated in PID patients compared with that in normal controls and decreased significantly compared with that in the same patients after they received treatment. PID patients with myeloperoxidase G/A alleles significantly tended to have elevated plasma concentration of myeloperoxidase, whereas PID patients with G/G homozygous alleles did not. Conclusion(s): Elevated expression of myeloperoxidase may be involved in the pathogenesis of PID and could be useful for the diagnosis of PID. Furthermore, G/A alleles of myeloperoxidase may contribute to such elevation in PID patients.",
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AU - Tsai, Hsiu Ting

AU - Yang, Shun Fa

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N2 - Objective: To compared the plasma levels and the genetic polymorphism of myeloperoxidase in patients with pelvic inflammatory disease (PID) and healthy controls. Design: A random consecutive study. Setting: University hospital. Patient(s): Forty-four women who were diagnosed with PID. Intervention(s): Collected blood specimens of patients before and after they received treatment. Main Outcome Measure(s): ELISA and polymerase chain reaction-restriction fragment length polymorphism were respectively used to measure the plasma levels and genetic polymorphism of myeloperoxidase. Result(s): We found the plasma level of myeloperoxidase was elevated in PID patients compared with that in normal controls and decreased significantly compared with that in the same patients after they received treatment. PID patients with myeloperoxidase G/A alleles significantly tended to have elevated plasma concentration of myeloperoxidase, whereas PID patients with G/G homozygous alleles did not. Conclusion(s): Elevated expression of myeloperoxidase may be involved in the pathogenesis of PID and could be useful for the diagnosis of PID. Furthermore, G/A alleles of myeloperoxidase may contribute to such elevation in PID patients.

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