Maresin 1 biosynthesis and proresolving anti-infective functions with human-localized aggressive periodontitis leukocytes

Chin Wei Wang, Romain A. Colas, Jesmond Dalli, Hildur H. Arnardottir, Daniel Nguyen, Hatice Hasturk, Nan Chiang, Thomas E. Van Dyke, Charles N. Serhan

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44 引文 斯高帕斯(Scopus)


Localized aggressive periodontitis (LAP) is a distinct form of early-onset periodontitis linked to periodontal infection with uncontrolled inflammation and leukocyte-mediated tissue destruction. The resolution of inflammation is an active process orchestrated by specialized proresolving lipid mediators (SPMs). Since the level of the Maresin pathway marker 14-hydroxy-docosahexaenoic acid (14-HDHA) was lower in activated peripheral blood from LAP patients, we investigated the Maresin 1 (MaR1) biosynthetic pathway in these subjects and its role in regulating phagocyte functions. Macrophages from LAP patients had a lower level of expression of 12-lipoxygenase (~30%) and reduced MaR1 (LAP versus healthy controls [HC], 87.8 ± 50 pg/106 cells versus 239.1 ± 32 pg/106 cells). Phagocytosis by LAP macrophages was reduced ~40% compared to that of HC, and killing of periodontal pathogens, including Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, were similarly reduced. LAP neutrophils also displayed slower kinetics (~30%) and decreased maximal phagocytosis (~20% lower) with these pathogens than those of HC. The administration of MaR1 at 1 nM enhanced phagocytosis (31 to 65% increase), intracellular antimicrobial reactive oxygen species production (26 to 71% increase), bacterial killing of these periodontal pathogens (22 to 38% reduction of bacterial titers), and restored impairment of LAP phagocytes. Together, these results suggest that therapeutics targeting the Maresin pathway have clinical utility in treating LAP and other oral diseases associated with infection, inflammation, and altered phagocyte functions.
頁(從 - 到)658-665
期刊Infection and Immunity
出版狀態已發佈 - 3月 2016

ASJC Scopus subject areas

  • 寄生物學
  • 微生物學
  • 免疫學
  • 傳染性疾病


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