Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in lymphoblastoid tumors

Dan Jones, Lucy Lee, Juinn Lin Liu, Hsing Jien Rung, Joanne K. Tillotson

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200 引文 斯高帕斯(Scopus)

摘要

Marek disease virus (MDV) is a herpesvirus of chickens that induces T lymphomas within 3 weeks of infection. The short latency and polyclonal nature of MDV-induced tumors have suggested that the virus may encode one or more direct-acting oncogenes. To date, however, no MDV-specific tumor antigens or candidate transforming genes have been demonstrated. In this paper, we report the identification of a MDV gene encoding a protein with homology to the leucine-zipper class of nuclear oncogenes. It also contains a proline-rich domain characteristic of another class of transcription factors. This gene, designated meq, maps to the long repeat of MDV and is one of the few genes that are highly expressed in MDV-induced T-cell tumors. To our knowledge, a herpesvirus gene closely related to the fos/jun family of oncogenes has not been reported previously.
原文英語
頁(從 - 到)4042-4046
頁數5
期刊Proceedings of the National Academy of Sciences of the United States of America
89
發行號9
DOIs
出版狀態已發佈 - 一月 1 1992
對外發佈

ASJC Scopus subject areas

  • 多學科

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