摘要
The present study was designed to determine the effect of various core temperatures on acute lung injury induced by ischemia-reperfusion (I/R) in our isolated rabbit lung model. Typical acute lung injury was successfully induced by 30 min of ischemia followed by 90 min of reperfusion observation. The I/R elicited a significant increase in pulmonary arterial pressure, microvascular permeability (measured by using the capillary filtration coefficient, Kfc), ΔKfc ratio, lung weight gain and the protein concentration of the bronchoalveolar lavage fluid. Mild hypothermia significantly attenuated acute lung injury induced by I/R, all parameters having decreased significantly (p<0.05); conversely, mild hyperthermia did not further exacerbate acute lung injury. These experimental data suggest that mild hypothermia significantly ameliorated acute lung injury induced by ischemia-reperfusion in rabbits.
原文 | 英語 |
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頁(從 - 到) | 285-291 |
頁數 | 7 |
期刊 | Pulmonary Pharmacology and Therapeutics |
卷 | 21 |
發行號 | 2 |
DOIs | |
出版狀態 | 已發佈 - 4月 2008 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 肺和呼吸系統醫學
- 生物化學(醫學)
- 藥學(醫學)