Manipulations of core temperatures in ischemia-reperfusion lung injury in rabbits

Hung Chang; Kun Lun Huang; Min Hui Li; Ching Wang Hsu; Shih Hung Tsai; Shi Jye Chu

doi:10.1016/j.pupt.2007.06.001

Manipulations of core temperatures in ischemia-reperfusion lung injury in rabbits

Hung Chang, Kun Lun Huang, Min Hui Li, Ching Wang Hsu, Shih Hung Tsai, Shi Jye Chu

研究成果: 雜誌貢獻 › 文章 › 同行評審

4 引文斯高帕斯（Scopus）

摘要

The present study was designed to determine the effect of various core temperatures on acute lung injury induced by ischemia-reperfusion (I/R) in our isolated rabbit lung model. Typical acute lung injury was successfully induced by 30 min of ischemia followed by 90 min of reperfusion observation. The I/R elicited a significant increase in pulmonary arterial pressure, microvascular permeability (measured by using the capillary filtration coefficient, K_fc), ΔK_fc ratio, lung weight gain and the protein concentration of the bronchoalveolar lavage fluid. Mild hypothermia significantly attenuated acute lung injury induced by I/R, all parameters having decreased significantly (p

原文	英語
頁（從 - 到）	285-291
頁數	7
期刊	Pulmonary Pharmacology and Therapeutics
卷	21
發行號	2
DOIs	https://doi.org/10.1016/j.pupt.2007.06.001
出版狀態	已發佈 - 四月 2008
對外發佈	Yes

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Pharmacology

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10.1016/j.pupt.2007.06.001

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abstract = "The present study was designed to determine the effect of various core temperatures on acute lung injury induced by ischemia-reperfusion (I/R) in our isolated rabbit lung model. Typical acute lung injury was successfully induced by 30 min of ischemia followed by 90 min of reperfusion observation. The I/R elicited a significant increase in pulmonary arterial pressure, microvascular permeability (measured by using the capillary filtration coefficient, Kfc), ΔKfc ratio, lung weight gain and the protein concentration of the bronchoalveolar lavage fluid. Mild hypothermia significantly attenuated acute lung injury induced by I/R, all parameters having decreased significantly (p",

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