Manipulations of core temperatures in ischemia-reperfusion lung injury in rabbits

Hung Chang; Kun Lun Huang; Min Hui Li; Ching Wang Hsu; Shih Hung Tsai; Shi Jye Chu

doi:10.1016/j.pupt.2007.06.001

Manipulations of core temperatures in ischemia-reperfusion lung injury in rabbits

Hung Chang, Kun Lun Huang, Min Hui Li, Ching Wang Hsu, Shih Hung Tsai, Shi Jye Chu

研究成果: 雜誌貢獻 › 文章 › 同行評審

4 引文斯高帕斯（Scopus）

摘要

The present study was designed to determine the effect of various core temperatures on acute lung injury induced by ischemia-reperfusion (I/R) in our isolated rabbit lung model. Typical acute lung injury was successfully induced by 30 min of ischemia followed by 90 min of reperfusion observation. The I/R elicited a significant increase in pulmonary arterial pressure, microvascular permeability (measured by using the capillary filtration coefficient, K_fc), ΔK_fc ratio, lung weight gain and the protein concentration of the bronchoalveolar lavage fluid. Mild hypothermia significantly attenuated acute lung injury induced by I/R, all parameters having decreased significantly (p<0.05); conversely, mild hyperthermia did not further exacerbate acute lung injury. These experimental data suggest that mild hypothermia significantly ameliorated acute lung injury induced by ischemia-reperfusion in rabbits.

原文	英語
頁（從 - 到）	285-291
頁數	7
期刊	Pulmonary Pharmacology and Therapeutics
卷	21
發行號	2
DOIs	https://doi.org/10.1016/j.pupt.2007.06.001
出版狀態	已發佈 - 四月 2008
對外發佈	是

ASJC Scopus subject areas

肺和呼吸系統醫學
生物化學（醫學）
藥學（醫學）

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10.1016/j.pupt.2007.06.001

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title = "Manipulations of core temperatures in ischemia-reperfusion lung injury in rabbits",

abstract = "The present study was designed to determine the effect of various core temperatures on acute lung injury induced by ischemia-reperfusion (I/R) in our isolated rabbit lung model. Typical acute lung injury was successfully induced by 30 min of ischemia followed by 90 min of reperfusion observation. The I/R elicited a significant increase in pulmonary arterial pressure, microvascular permeability (measured by using the capillary filtration coefficient, Kfc), ΔKfc ratio, lung weight gain and the protein concentration of the bronchoalveolar lavage fluid. Mild hypothermia significantly attenuated acute lung injury induced by I/R, all parameters having decreased significantly (p<0.05); conversely, mild hyperthermia did not further exacerbate acute lung injury. These experimental data suggest that mild hypothermia significantly ameliorated acute lung injury induced by ischemia-reperfusion in rabbits.",

keywords = "Acute lung injury, Hyperthermia, Hypothermia, Ischemia-reperfusion injury",

author = "Hung Chang and Huang, {Kun Lun} and Li, {Min Hui} and Hsu, {Ching Wang} and Tsai, {Shih Hung} and Chu, {Shi Jye}",

note = "Funding Information: This study was supported, in part, by National Science Council of Taiwan Grant NSC 94-2314-B-016-067 and Grant TSGH-C95-37 from Tri-Service General Hospital.",

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AU - Huang, Kun Lun

AU - Li, Min Hui

AU - Hsu, Ching Wang

AU - Tsai, Shih Hung

AU - Chu, Shi Jye

N1 - Funding Information: This study was supported, in part, by National Science Council of Taiwan Grant NSC 94-2314-B-016-067 and Grant TSGH-C95-37 from Tri-Service General Hospital.

PY - 2008/4

Y1 - 2008/4

N2 - The present study was designed to determine the effect of various core temperatures on acute lung injury induced by ischemia-reperfusion (I/R) in our isolated rabbit lung model. Typical acute lung injury was successfully induced by 30 min of ischemia followed by 90 min of reperfusion observation. The I/R elicited a significant increase in pulmonary arterial pressure, microvascular permeability (measured by using the capillary filtration coefficient, Kfc), ΔKfc ratio, lung weight gain and the protein concentration of the bronchoalveolar lavage fluid. Mild hypothermia significantly attenuated acute lung injury induced by I/R, all parameters having decreased significantly (p<0.05); conversely, mild hyperthermia did not further exacerbate acute lung injury. These experimental data suggest that mild hypothermia significantly ameliorated acute lung injury induced by ischemia-reperfusion in rabbits.

AB - The present study was designed to determine the effect of various core temperatures on acute lung injury induced by ischemia-reperfusion (I/R) in our isolated rabbit lung model. Typical acute lung injury was successfully induced by 30 min of ischemia followed by 90 min of reperfusion observation. The I/R elicited a significant increase in pulmonary arterial pressure, microvascular permeability (measured by using the capillary filtration coefficient, Kfc), ΔKfc ratio, lung weight gain and the protein concentration of the bronchoalveolar lavage fluid. Mild hypothermia significantly attenuated acute lung injury induced by I/R, all parameters having decreased significantly (p<0.05); conversely, mild hyperthermia did not further exacerbate acute lung injury. These experimental data suggest that mild hypothermia significantly ameliorated acute lung injury induced by ischemia-reperfusion in rabbits.

KW - Acute lung injury

KW - Hyperthermia

KW - Hypothermia

KW - Ischemia-reperfusion injury

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Manipulations of core temperatures in ischemia-reperfusion lung injury in rabbits

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