Manganese superoxide dismutase gene polymorphisms in psoriatic arthritis

Jeng Hsien Yen, Wen Chun Tsai, Chia H. Lin, Tsan Teng Ou, Chaur Jong Hu, Hong W. Liu

研究成果: 雜誌貢獻文章同行評審

5 引文 斯高帕斯(Scopus)

摘要

The purpose of the present study is to investigate the role of manganese superoxide dismutase (MnSOD) gene polymorphisms in the susceptibility to psoriatic arthritis. MnSOD gene polymorphisms were determined by polymerase chain reaction/restriction fragment length polymorphisms method in fifty-two patients with psoriatic arthritis and 90 healthy controls. The genotype frequency of MnSOD 1183C/T was significantly higher in patients with psoriatic arthritis than in controls. In contrast, the frequency of MnSOD 1183T/T was significantly decreased in patients with psoriatic arthritis. The phenotype frequency of MnSOD 1183C was significantly increased in patients with psoriatics arthritis in comparison to healthy controls. Therefore, MnSOD 1183C polymorphisms may be a precipitating factor for the development of psoriatic arthritis.

原文英語
頁(從 - 到)263-265
頁數3
期刊Disease Markers
19
發行號6
出版狀態已發佈 - 2003
對外發佈

ASJC Scopus subject areas

  • 臨床生物化學
  • 醫藥 (全部)

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