Mammalian target of rapamycin and head and neck squamous cell carcinoma

Yu Min Liao, Charles Kim, Yun Yen

研究成果: 雜誌貢獻回顧型文獻同行評審

22 引文 斯高帕斯(Scopus)

摘要

Head and neck squamous cell carcinoma (HNSCC), a significant cause of cancer deaths worldwide, has multiple stepwise malignant evolutions. Mammalian target of rapamycin (mTOR) plays a critical role in tumor development, invasion, metastasis and angiogenesis that impact local recurrence and survival. mTOR can also act as a biomarker for personalized adjuvant therapy. In in vivo and in vitro studies, mTOR inhibitor suppresses tumor growth and sensitizes HNSCC to radiation, cytotoxic agents and epidermoid growth factor receptor inhibitors. We have reviewed the pathogenesis of HNSCC, mTOR pathway, mTOR inhibitor and the role of mTOR in HNSCC.

原文英語
文章編號22
期刊Head and Neck Oncology
3
發行號1
DOIs
出版狀態已發佈 - 四月 26 2011
對外發佈

ASJC Scopus subject areas

  • 耳鼻咽喉科
  • 腫瘤科

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