Malignancy of intracerebral lesions evaluated with 11C- methionine-PET

Ming Chao Huang, Yang Hsin Shih, Ming Hsiung Chen, Wen Yuh Chung, Donald Ming Tak Ho, Ren Shyan Liu, Liang Ming Lee, Chun I. Huang, Liang Shong Lee, Henrich Cheng

研究成果: 雜誌貢獻文章

10 引文 (Scopus)

摘要

Positron emission tomography (PET) allows examination of a variety of physiological parameter, including blood flow, glucose, amino acid and oxygen metabolism. However, correlation of PET scan findings and the degree of malignancy of intracerebral tumors continues to be controversial. Nine patients with primarily diagnosed intraparenchymal brain tumors were included in this study. We performed 11C-methionine-PET (met-PET) prior to surgical treatment and the differential absorption ratio (DAR) was calculated. All patients underwent open or stereotactic surgery and specimens for pathological diagnosis were obtained. The biological activity of each tumor was determined by calculation of the proliferation index from MIB-1 immunohistochemistry. The DAR of met-PET for individual tumors correlated with the histological diagnosis and degree of malignancy and this was further confirmed by good correlation with the MIB-1 proliferation index. We conclude that met-PET may be a reliable and effective preoperative evaluation to determine the type and malignancy of intraparenchymal brain lesions.
原文英語
頁(從 - 到)775-780
頁數6
期刊Journal of Clinical Neuroscience
12
發行號7
DOIs
出版狀態已發佈 - 九月 2005

指紋

Methionine
Positron-Emission Tomography
Neoplasms
Brain Neoplasms
Blood Glucose
Immunohistochemistry
Oxygen
Amino Acids
Brain

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology

引用此文

Huang, M. C., Shih, Y. H., Chen, M. H., Chung, W. Y., Ho, D. M. T., Liu, R. S., ... Cheng, H. (2005). Malignancy of intracerebral lesions evaluated with 11C- methionine-PET. Journal of Clinical Neuroscience, 12(7), 775-780. https://doi.org/10.1016/j.jocn.2005.07.001

Malignancy of intracerebral lesions evaluated with 11C- methionine-PET. / Huang, Ming Chao; Shih, Yang Hsin; Chen, Ming Hsiung; Chung, Wen Yuh; Ho, Donald Ming Tak; Liu, Ren Shyan; Lee, Liang Ming; Huang, Chun I.; Lee, Liang Shong; Cheng, Henrich.

於: Journal of Clinical Neuroscience, 卷 12, 編號 7, 09.2005, p. 775-780.

研究成果: 雜誌貢獻文章

Huang, MC, Shih, YH, Chen, MH, Chung, WY, Ho, DMT, Liu, RS, Lee, LM, Huang, CI, Lee, LS & Cheng, H 2005, 'Malignancy of intracerebral lesions evaluated with 11C- methionine-PET', Journal of Clinical Neuroscience, 卷 12, 編號 7, 頁 775-780. https://doi.org/10.1016/j.jocn.2005.07.001
Huang, Ming Chao ; Shih, Yang Hsin ; Chen, Ming Hsiung ; Chung, Wen Yuh ; Ho, Donald Ming Tak ; Liu, Ren Shyan ; Lee, Liang Ming ; Huang, Chun I. ; Lee, Liang Shong ; Cheng, Henrich. / Malignancy of intracerebral lesions evaluated with 11C- methionine-PET. 於: Journal of Clinical Neuroscience. 2005 ; 卷 12, 編號 7. 頁 775-780.
@article{d02b6a5010504f5297bbcf03c0d971f9,
title = "Malignancy of intracerebral lesions evaluated with 11C- methionine-PET",
abstract = "Positron emission tomography (PET) allows examination of a variety of physiological parameter, including blood flow, glucose, amino acid and oxygen metabolism. However, correlation of PET scan findings and the degree of malignancy of intracerebral tumors continues to be controversial. Nine patients with primarily diagnosed intraparenchymal brain tumors were included in this study. We performed 11C-methionine-PET (met-PET) prior to surgical treatment and the differential absorption ratio (DAR) was calculated. All patients underwent open or stereotactic surgery and specimens for pathological diagnosis were obtained. The biological activity of each tumor was determined by calculation of the proliferation index from MIB-1 immunohistochemistry. The DAR of met-PET for individual tumors correlated with the histological diagnosis and degree of malignancy and this was further confirmed by good correlation with the MIB-1 proliferation index. We conclude that met-PET may be a reliable and effective preoperative evaluation to determine the type and malignancy of intraparenchymal brain lesions.",
keywords = "Brain neoplasm, Emission-computed, Glioma, Ki-67 antigen, Methionine, Tomography",
author = "Huang, {Ming Chao} and Shih, {Yang Hsin} and Chen, {Ming Hsiung} and Chung, {Wen Yuh} and Ho, {Donald Ming Tak} and Liu, {Ren Shyan} and Lee, {Liang Ming} and Huang, {Chun I.} and Lee, {Liang Shong} and Henrich Cheng",
year = "2005",
month = "9",
doi = "10.1016/j.jocn.2005.07.001",
language = "English",
volume = "12",
pages = "775--780",
journal = "Journal of Clinical Neuroscience",
issn = "0967-5868",
publisher = "Churchill Livingstone",
number = "7",

}

TY - JOUR

T1 - Malignancy of intracerebral lesions evaluated with 11C- methionine-PET

AU - Huang, Ming Chao

AU - Shih, Yang Hsin

AU - Chen, Ming Hsiung

AU - Chung, Wen Yuh

AU - Ho, Donald Ming Tak

AU - Liu, Ren Shyan

AU - Lee, Liang Ming

AU - Huang, Chun I.

AU - Lee, Liang Shong

AU - Cheng, Henrich

PY - 2005/9

Y1 - 2005/9

N2 - Positron emission tomography (PET) allows examination of a variety of physiological parameter, including blood flow, glucose, amino acid and oxygen metabolism. However, correlation of PET scan findings and the degree of malignancy of intracerebral tumors continues to be controversial. Nine patients with primarily diagnosed intraparenchymal brain tumors were included in this study. We performed 11C-methionine-PET (met-PET) prior to surgical treatment and the differential absorption ratio (DAR) was calculated. All patients underwent open or stereotactic surgery and specimens for pathological diagnosis were obtained. The biological activity of each tumor was determined by calculation of the proliferation index from MIB-1 immunohistochemistry. The DAR of met-PET for individual tumors correlated with the histological diagnosis and degree of malignancy and this was further confirmed by good correlation with the MIB-1 proliferation index. We conclude that met-PET may be a reliable and effective preoperative evaluation to determine the type and malignancy of intraparenchymal brain lesions.

AB - Positron emission tomography (PET) allows examination of a variety of physiological parameter, including blood flow, glucose, amino acid and oxygen metabolism. However, correlation of PET scan findings and the degree of malignancy of intracerebral tumors continues to be controversial. Nine patients with primarily diagnosed intraparenchymal brain tumors were included in this study. We performed 11C-methionine-PET (met-PET) prior to surgical treatment and the differential absorption ratio (DAR) was calculated. All patients underwent open or stereotactic surgery and specimens for pathological diagnosis were obtained. The biological activity of each tumor was determined by calculation of the proliferation index from MIB-1 immunohistochemistry. The DAR of met-PET for individual tumors correlated with the histological diagnosis and degree of malignancy and this was further confirmed by good correlation with the MIB-1 proliferation index. We conclude that met-PET may be a reliable and effective preoperative evaluation to determine the type and malignancy of intraparenchymal brain lesions.

KW - Brain neoplasm

KW - Emission-computed

KW - Glioma

KW - Ki-67 antigen

KW - Methionine

KW - Tomography

UR - http://www.scopus.com/inward/record.url?scp=26244459184&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=26244459184&partnerID=8YFLogxK

U2 - 10.1016/j.jocn.2005.07.001

DO - 10.1016/j.jocn.2005.07.001

M3 - Article

C2 - 16198917

AN - SCOPUS:26244459184

VL - 12

SP - 775

EP - 780

JO - Journal of Clinical Neuroscience

JF - Journal of Clinical Neuroscience

SN - 0967-5868

IS - 7

ER -