Main pulmonary arterial distensibility - Different presentation between chronic pulmonary hypertension and acute pulmonary embolism

Den Ko Wu, Shih Hung Hsiao, Shih Kai Lin, Chiu Yen Lee, Shu Hsin Yang, Shu Mei Chang, Kuan Rau Chiou

研究成果: 雜誌貢獻文章同行評審

17 引文 斯高帕斯(Scopus)

摘要

Background: The main pulmonary arterial (PA) distensibility in patients with pulmonary hypertension (PH) and pulmonary embolism (PE) is uncertain. Methods and Results: We enrolled 45 patients with echocardiographic signs of PH and without imaging evidence of PE, and another 45 who were found by multidetector-row computed tomography to have PE. Fifty normal patients served as a control group. The PA distensibility was calculated from the change in main PA diameter between diastole and systole, as the maximal systolic diameter minus the minimal diastolic diameter divided by the minimal diastolic diameter. The PA distensibility is lowest in PH (6.0±2.7%), followed by PE (12.9±3.4%) and then the normal controls (25.9±5.7%). Statistical analysis of data obtained from patients with PE or PH reveals that a PA distensibility of >8.3% could be used to identify PE with a sensitivity of 83% and a specificity of 82%. After a 3-month anticoagulation, 22 of 45 PE patients had complete resolution of thrombus; 23 had residual thrombus. The PE patients, regardless of residual thrombus presence, had significant improvement of PA distensibility after a 3-month anticoagulation, although the diameters of main PA did not shrink. Conclusion: PA distensibility is a method to distinguish acute PE from chronic PH.
原文英語
頁(從 - 到)1454-1459
頁數6
期刊Circulation Journal
72
發行號9
DOIs
出版狀態已發佈 - 九月 4 2008
對外發佈Yes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

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