Magnolol nanoparticles exhibit improved water solubility and suppress TNF-α-induced VCAM-1 expression in endothelial cells

Chiang Wen Lee, Stephen Chu Sung Hu, Feng Lin Yen, Lee Fen Hsu, I-Ta Lee, Zih Chan Lin, Ming Horng Tsai, Chieh Liang Huang, Chan Jung Liang, Yao Chang Chiang

研究成果: 雜誌貢獻文章

5 引文 斯高帕斯(Scopus)

摘要

The expression of the adhesion molecule vascular cell adhesion molecule-1 (VCAM-1) on endothelial cells enables the attachment of leukocytes to the endothelium, which may lead to inflammation and the development of atherosclerosis. Magnolol is a major bioactive compound derived from the plant species Magnolia officinalis. In this study, we synthesized a novel nanoparticle formulation of magnolol to improve its water solubility and physicochemical properties, evaluated its effects on TNF-α-induced VCAM-1 expression in endothelial cells, and determined the signal transduction pathways involved. Our findings demonstrated that the magnolol nanoparticle system showed great improvements in physicochemical properties and water solubility owing to a reduction in particle size, transformation from a crystalline to amorphous structure, and the formation of hydrogen bonds with the nanoparticle carriers. In terms of its biological actions, magnolol nanoparticles attenuated TNF-α-induced VCAM-1 protein expression, promoter activity, and mRNA expression in endothelial cells in vitro. This was found to be mediated by the ERK, AKT, and NF-κB signaling pathways. In addition, magnolol nanoparticles inhibited TNF-α-induced leukocyte adhesion to endothelial cells, and suppressed TNF-α-induced VCAM-1 expression in the aortic endothelium of mice. In summary, since magnolol nanoparticles inhibit endothelial VCAM-1 expression and leukocyte adhesion to endothelial cells, this novel drug formulation may be a potentially useful therapeutic formulation to prevent the development of atherosclerosis and inflammatory diseases.
原文英語
頁(從 - 到)255-268
頁數14
期刊Journal of Biomedical Nanotechnology
13
發行號3
DOIs
出版狀態已發佈 - 三月 1 2017
對外發佈Yes

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

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  • 引用此

    Lee, C. W., Hu, S. C. S., Yen, F. L., Hsu, L. F., Lee, I-T., Lin, Z. C., Tsai, M. H., Huang, C. L., Liang, C. J., & Chiang, Y. C. (2017). Magnolol nanoparticles exhibit improved water solubility and suppress TNF-α-induced VCAM-1 expression in endothelial cells. Journal of Biomedical Nanotechnology, 13(3), 255-268. https://doi.org/10.1166/jbn.2017.2342