Magnetic resonance imaging of tophaceous gout

Hsin Chi Chen, Tiffany Ting Fang Shih, Chau Yu Hsu, Chi Long Chen, Kou Mou Huang, Yiu Wah Li

研究成果: 雜誌貢獻文章

1 引文 (Scopus)

摘要

Gouty arthritis is a common disease, and tophi represent the chronic phase of the disease process. A tophus consists of a core of monosodium urate (MSU) crystals surrounded by various degrees of vascularity of inflammatory tissue. We retrospectively reviewed the magnetic resonance (MR) images of 16 joints with tophaceous gout encountered in 14 patients. Totally 18 lesions of tophaceous mass were identified among the 14 patients. The MR images were evaluated for signal intensity characteristics and patterns of enhancement of tophi, and these findings were correlated with pathologic examinations in eight lesions. On T1-weighted images, signal intensity of tophi was low when compared with adjacent skeletal muscle in all 18 lesions. The signal intensity of tophi on T2-weighted images was more variable. Twelve of 18 lesions appeared as an area of high signal intensity, and as an area of low signal intensity in 6 of the 18 lesions, compared with adjacent skeletal muscle. Within the T2-weighted high-signal tophi, dot-like low-signal areas on both T1- and T2-weighted images were also noted in 11 of the 12 lesions. On post-enhanced images, all 12 high-signal tophi exhibited moderate, heterogeneous enhancement. In two of these 12, additional marginal enhancement was also noted in different regions of the lesions. Four of the six lesions with T2-weighted low-signal tophi underwent post-enhancement studies and showed poor enhancement in all lesions. The authors conclude that the signal intensity of tophi is constant on T1-but quite variable on T2- weighted and post-enhancement images. The presence of high signal intensity and enhancement could be related to the increased vascularity of adjacent affected synovium and hypervascular granulation tissues within the tophi.

原文英語
頁(從 - 到)147-152
頁數6
期刊Chinese Journal of Radiology
24
發行號4
出版狀態已發佈 - 八月 1999
對外發佈Yes

指紋

Gout
Skeletal Muscle
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Gouty Arthritis
Image Enhancement
Granulation Tissue
Synovial Membrane
Uric Acid
Chronic Disease
Joints

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

引用此文

Chen, H. C., Shih, T. T. F., Hsu, C. Y., Chen, C. L., Huang, K. M., & Li, Y. W. (1999). Magnetic resonance imaging of tophaceous gout. Chinese Journal of Radiology, 24(4), 147-152.

Magnetic resonance imaging of tophaceous gout. / Chen, Hsin Chi; Shih, Tiffany Ting Fang; Hsu, Chau Yu; Chen, Chi Long; Huang, Kou Mou; Li, Yiu Wah.

於: Chinese Journal of Radiology, 卷 24, 編號 4, 08.1999, p. 147-152.

研究成果: 雜誌貢獻文章

Chen, HC, Shih, TTF, Hsu, CY, Chen, CL, Huang, KM & Li, YW 1999, 'Magnetic resonance imaging of tophaceous gout', Chinese Journal of Radiology, 卷 24, 編號 4, 頁 147-152.
Chen HC, Shih TTF, Hsu CY, Chen CL, Huang KM, Li YW. Magnetic resonance imaging of tophaceous gout. Chinese Journal of Radiology. 1999 8月;24(4):147-152.
Chen, Hsin Chi ; Shih, Tiffany Ting Fang ; Hsu, Chau Yu ; Chen, Chi Long ; Huang, Kou Mou ; Li, Yiu Wah. / Magnetic resonance imaging of tophaceous gout. 於: Chinese Journal of Radiology. 1999 ; 卷 24, 編號 4. 頁 147-152.
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abstract = "Gouty arthritis is a common disease, and tophi represent the chronic phase of the disease process. A tophus consists of a core of monosodium urate (MSU) crystals surrounded by various degrees of vascularity of inflammatory tissue. We retrospectively reviewed the magnetic resonance (MR) images of 16 joints with tophaceous gout encountered in 14 patients. Totally 18 lesions of tophaceous mass were identified among the 14 patients. The MR images were evaluated for signal intensity characteristics and patterns of enhancement of tophi, and these findings were correlated with pathologic examinations in eight lesions. On T1-weighted images, signal intensity of tophi was low when compared with adjacent skeletal muscle in all 18 lesions. The signal intensity of tophi on T2-weighted images was more variable. Twelve of 18 lesions appeared as an area of high signal intensity, and as an area of low signal intensity in 6 of the 18 lesions, compared with adjacent skeletal muscle. Within the T2-weighted high-signal tophi, dot-like low-signal areas on both T1- and T2-weighted images were also noted in 11 of the 12 lesions. On post-enhanced images, all 12 high-signal tophi exhibited moderate, heterogeneous enhancement. In two of these 12, additional marginal enhancement was also noted in different regions of the lesions. Four of the six lesions with T2-weighted low-signal tophi underwent post-enhancement studies and showed poor enhancement in all lesions. The authors conclude that the signal intensity of tophi is constant on T1-but quite variable on T2- weighted and post-enhancement images. The presence of high signal intensity and enhancement could be related to the increased vascularity of adjacent affected synovium and hypervascular granulation tissues within the tophi.",
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