4 引文 (Scopus)

摘要

BACKGROUND: Magnetic resonance-guided focused ultrasound (MRgFUS) is an alternative local therapy for patients with painful bone metastasis for whom standard conventional radiation therapy (RT) has failed. However, the therapeutic effects of MRgFUS as a first-line treatment for bone metastasis remain uncertain.

METHODS: A matched-pair study was conducted to compare the therapeutic effects of MRgFUS with those of conventional RT as a first-line treatment for patients with painful bone metastasis. The MRgFUS and RT-treated groups were matched 1:2 by age, sex, primary cancer, pretreatment pain score, and treated site.

RESULTS: According to the criteria for patient eligibility and matching, 21 and 42 patients (total, 63 patients) with bone metastasis treated with MRgFUS and conventional RT, respectively, were enrolled for analyses. The median ages of the MRgFUS and RT-treated patients were 59 and 61 years, respectively. Among the enrolled patients, 52% were male and 48% were female. The results showed that both MRgFUS and RT were effective. However, MRgFUS was more efficient than RT in terms of the time course of pain palliation as it yielded a significantly higher response rate at 1 week after treatment (71% versus 26%, p = 0.0009).

CONCLUSIONS: MRgFUS provides a similar overall treatment response rate but faster pain relief compared with conventional RT and has the potential to serve as the first-line treatment for painful bone metastasis in selected patients.

LEVEL OF EVIDENCE: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
原文英語
頁(從 - 到)1572-1578
頁數7
期刊The Journal of bone and joint surgery. American volume
99
發行號18
DOIs
出版狀態已發佈 - 九月 20 2017

指紋

Magnetic Resonance Spectroscopy
Radiotherapy
Neoplasm Metastasis
Bone and Bones
Therapeutic Uses
Therapeutics
Pain
Complementary Therapies
Research Design
Ultrasonic Waves

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

引用此文

@article{e5f2e90462fd4d03b7b0409e75425ca6,
title = "Magnetic Resonance-Guided Focused Ultrasound Versus Conventional Radiation Therapy for Painful Bone Metastasis: A Matched-Pair Study",
abstract = "BACKGROUND: Magnetic resonance-guided focused ultrasound (MRgFUS) is an alternative local therapy for patients with painful bone metastasis for whom standard conventional radiation therapy (RT) has failed. However, the therapeutic effects of MRgFUS as a first-line treatment for bone metastasis remain uncertain.METHODS: A matched-pair study was conducted to compare the therapeutic effects of MRgFUS with those of conventional RT as a first-line treatment for patients with painful bone metastasis. The MRgFUS and RT-treated groups were matched 1:2 by age, sex, primary cancer, pretreatment pain score, and treated site.RESULTS: According to the criteria for patient eligibility and matching, 21 and 42 patients (total, 63 patients) with bone metastasis treated with MRgFUS and conventional RT, respectively, were enrolled for analyses. The median ages of the MRgFUS and RT-treated patients were 59 and 61 years, respectively. Among the enrolled patients, 52{\%} were male and 48{\%} were female. The results showed that both MRgFUS and RT were effective. However, MRgFUS was more efficient than RT in terms of the time course of pain palliation as it yielded a significantly higher response rate at 1 week after treatment (71{\%} versus 26{\%}, p = 0.0009).CONCLUSIONS: MRgFUS provides a similar overall treatment response rate but faster pain relief compared with conventional RT and has the potential to serve as the first-line treatment for painful bone metastasis in selected patients.LEVEL OF EVIDENCE: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.",
author = "Lee, {Hsin Lun} and Kuo, {Chia Chun} and Tsai, {Jo Ting} and Chen, {Chun You} and Wu, {Meng Huang} and Chiou, {Jeng Fong}",
year = "2017",
month = "9",
day = "20",
doi = "10.2106/JBJS.16.01248",
language = "English",
volume = "99",
pages = "1572--1578",
journal = "Journal of Bone and Joint Surgery - Series B",
issn = "0021-9355",
publisher = "Journal of Bone and Joint Surgery Inc.",
number = "18",

}

TY - JOUR

T1 - Magnetic Resonance-Guided Focused Ultrasound Versus Conventional Radiation Therapy for Painful Bone Metastasis

T2 - A Matched-Pair Study

AU - Lee, Hsin Lun

AU - Kuo, Chia Chun

AU - Tsai, Jo Ting

AU - Chen, Chun You

AU - Wu, Meng Huang

AU - Chiou, Jeng Fong

PY - 2017/9/20

Y1 - 2017/9/20

N2 - BACKGROUND: Magnetic resonance-guided focused ultrasound (MRgFUS) is an alternative local therapy for patients with painful bone metastasis for whom standard conventional radiation therapy (RT) has failed. However, the therapeutic effects of MRgFUS as a first-line treatment for bone metastasis remain uncertain.METHODS: A matched-pair study was conducted to compare the therapeutic effects of MRgFUS with those of conventional RT as a first-line treatment for patients with painful bone metastasis. The MRgFUS and RT-treated groups were matched 1:2 by age, sex, primary cancer, pretreatment pain score, and treated site.RESULTS: According to the criteria for patient eligibility and matching, 21 and 42 patients (total, 63 patients) with bone metastasis treated with MRgFUS and conventional RT, respectively, were enrolled for analyses. The median ages of the MRgFUS and RT-treated patients were 59 and 61 years, respectively. Among the enrolled patients, 52% were male and 48% were female. The results showed that both MRgFUS and RT were effective. However, MRgFUS was more efficient than RT in terms of the time course of pain palliation as it yielded a significantly higher response rate at 1 week after treatment (71% versus 26%, p = 0.0009).CONCLUSIONS: MRgFUS provides a similar overall treatment response rate but faster pain relief compared with conventional RT and has the potential to serve as the first-line treatment for painful bone metastasis in selected patients.LEVEL OF EVIDENCE: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.

AB - BACKGROUND: Magnetic resonance-guided focused ultrasound (MRgFUS) is an alternative local therapy for patients with painful bone metastasis for whom standard conventional radiation therapy (RT) has failed. However, the therapeutic effects of MRgFUS as a first-line treatment for bone metastasis remain uncertain.METHODS: A matched-pair study was conducted to compare the therapeutic effects of MRgFUS with those of conventional RT as a first-line treatment for patients with painful bone metastasis. The MRgFUS and RT-treated groups were matched 1:2 by age, sex, primary cancer, pretreatment pain score, and treated site.RESULTS: According to the criteria for patient eligibility and matching, 21 and 42 patients (total, 63 patients) with bone metastasis treated with MRgFUS and conventional RT, respectively, were enrolled for analyses. The median ages of the MRgFUS and RT-treated patients were 59 and 61 years, respectively. Among the enrolled patients, 52% were male and 48% were female. The results showed that both MRgFUS and RT were effective. However, MRgFUS was more efficient than RT in terms of the time course of pain palliation as it yielded a significantly higher response rate at 1 week after treatment (71% versus 26%, p = 0.0009).CONCLUSIONS: MRgFUS provides a similar overall treatment response rate but faster pain relief compared with conventional RT and has the potential to serve as the first-line treatment for painful bone metastasis in selected patients.LEVEL OF EVIDENCE: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.

UR - http://www.scopus.com/inward/record.url?scp=85030435853&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85030435853&partnerID=8YFLogxK

U2 - 10.2106/JBJS.16.01248

DO - 10.2106/JBJS.16.01248

M3 - Article

VL - 99

SP - 1572

EP - 1578

JO - Journal of Bone and Joint Surgery - Series B

JF - Journal of Bone and Joint Surgery - Series B

SN - 0021-9355

IS - 18

ER -