摘要

Lycopene is the most abundant carotenoid in tomatoes, which has been identified to have the properties of anti-inflammation in addition to the capability to inhibit the expression of adhesion molecules. Intercellular adhesion molecules play a critical role in the pathogenesis of psoriasis. Here, we report that the topical use of a lycopene decreased imiquimod (IMQ)-induced psoriasis-like inflammatory responses, the progress of which was based on adhesion molecules. In vitro analysis showed that lycopene decreased keratinocyte and monocyte adhesion. Evidence suggests that intercellular adhesion molecule-1 (ICAM-1) is a main mediator of psoriasis pathogenesis. Therefore, it will be interesting to investigate the factors that contribute to the lycopene-mediated inhibition of ICAM-1 expression in psoriasis. We expect that lycopene will with potential value in the treatment of psoriasis.
原文英語
文章編號1521
期刊Polymers
12
發行號7
DOIs
出版狀態已發佈 - 七月 1 2020

ASJC Scopus subject areas

  • 化學 (全部)
  • 聚合物和塑料

指紋

深入研究「Lycopene inhibit IMQ-induced psoriasis-like inflammation by inhibiting ICAM-1 production in Mice」主題。共同形成了獨特的指紋。

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