LV-Only and LV-First Pacing Demonstrate Greater Improvements in Acute Hemodynamics Than Synchronous BiV Pacing in Heart Failure With Preserved Ejection Fraction

Y.C. Wang, C.C. Yu, Ruth N. Klepfer, Katherine Hilpisch, Vince Splett, L.Y. Lin, F.C. Chiu, C.T. Tsai, L.P. Lai, J.J. Hwang, Jiunn-Lee Lin

研究成果: 雜誌貢獻文章

33 引文 (Scopus)

摘要

Background: Heart failure with a preserved ejection fraction (HFpEF) remains poorly understood with few options for treatment. Recent evidence identified regional delays in cardiac mechanical activation in HFpEF despite a narrow QRS and normal chamber size. We compared the acute effects of synchronous BiV pacing (VV0), BiV pacing with LV first (LVfirst) and LVonly (LVonly) pacing on mechanical dyssynchrony and hemodynamics in HFpEF. Methods: HF patients with EF O50% and echocardiographic evidence of dyssynchrony were studied during cardiac catheterization. Patients were instrumented with temporary pacing catheters in the RA, LV and RV, and paced in VDD mode with AV timing selected to optimize transmitral flow during simultaneous BiV pacing. A pressure catheter provided continuous LVand aortic pressure. LVonly, LVfirst and VV0 pacing were compared to normal sinus rhythm (NSR). During LVfirst pacing, the
LV was stimulated 45 ms before the RV. Regional mechanical delay (RMD) was measured in all pacing modes and during NSR.RMD isthe time difference between the septal and lateral wall peak myocardial velocities. Results: Eleven patients participated (71 yo, 82% female, NYHA class of 2.5, BMI of 28 kg/m2
). Patients had an EF of 74% and a narrow QRS (86 ms). LVonly and LVfirst significantly reduced systolic mechanical dyssynchrony, Ts-SD (standard deviation of time to peak systolic velocity of 12 ventricular segments) and RMD. However, E/E’ significantly decreased only during LVonly. Paradoxically, all three pacing modes also showed a significant increase in LVEDP. LVonly and LVfirst also demonstrated improvements in several measures of systolic function.
原文繁體中文
頁(從 - 到)S17
期刊Journal of Cardiac Failure
16
發行號8
DOIs
出版狀態已發佈 - 八月 1 2010
對外發佈Yes

引用此文

LV-Only and LV-First Pacing Demonstrate Greater Improvements in Acute Hemodynamics Than Synchronous BiV Pacing in Heart Failure With Preserved Ejection Fraction. / Wang, Y.C.; Yu, C.C.; Klepfer, Ruth N.; Hilpisch, Katherine; Splett, Vince; Lin, L.Y.; Chiu, F.C.; Tsai, C.T.; Lai, L.P.; Hwang, J.J.; Lin, Jiunn-Lee.

於: Journal of Cardiac Failure, 卷 16, 編號 8, 01.08.2010, p. S17.

研究成果: 雜誌貢獻文章

Wang, Y.C. ; Yu, C.C. ; Klepfer, Ruth N. ; Hilpisch, Katherine ; Splett, Vince ; Lin, L.Y. ; Chiu, F.C. ; Tsai, C.T. ; Lai, L.P. ; Hwang, J.J. ; Lin, Jiunn-Lee. / LV-Only and LV-First Pacing Demonstrate Greater Improvements in Acute Hemodynamics Than Synchronous BiV Pacing in Heart Failure With Preserved Ejection Fraction. 於: Journal of Cardiac Failure. 2010 ; 卷 16, 編號 8. 頁 S17.
@article{57eab0a0e933419488edda412ad5b714,
title = "LV-Only and LV-First Pacing Demonstrate Greater Improvements in Acute Hemodynamics Than Synchronous BiV Pacing in Heart Failure With Preserved Ejection Fraction",
abstract = "Background: Heart failure with a preserved ejection fraction (HFpEF) remains poorly understood with few options for treatment. Recent evidence identified regional delays in cardiac mechanical activation in HFpEF despite a narrow QRS and normal chamber size. We compared the acute effects of synchronous BiV pacing (VV0), BiV pacing with LV first (LVfirst) and LVonly (LVonly) pacing on mechanical dyssynchrony and hemodynamics in HFpEF. Methods: HF patients with EF O50{\%} and echocardiographic evidence of dyssynchrony were studied during cardiac catheterization. Patients were instrumented with temporary pacing catheters in the RA, LV and RV, and paced in VDD mode with AV timing selected to optimize transmitral flow during simultaneous BiV pacing. A pressure catheter provided continuous LVand aortic pressure. LVonly, LVfirst and VV0 pacing were compared to normal sinus rhythm (NSR). During LVfirst pacing, theLV was stimulated 45 ms before the RV. Regional mechanical delay (RMD) was measured in all pacing modes and during NSR.RMD isthe time difference between the septal and lateral wall peak myocardial velocities. Results: Eleven patients participated (71 yo, 82{\%} female, NYHA class of 2.5, BMI of 28 kg/m2). Patients had an EF of 74{\%} and a narrow QRS (86 ms). LVonly and LVfirst significantly reduced systolic mechanical dyssynchrony, Ts-SD (standard deviation of time to peak systolic velocity of 12 ventricular segments) and RMD. However, E/E’ significantly decreased only during LVonly. Paradoxically, all three pacing modes also showed a significant increase in LVEDP. LVonly and LVfirst also demonstrated improvements in several measures of systolic function.",
author = "Y.C. Wang and C.C. Yu and Klepfer, {Ruth N.} and Katherine Hilpisch and Vince Splett and L.Y. Lin and F.C. Chiu and C.T. Tsai and L.P. Lai and J.J. Hwang and Jiunn-Lee Lin",
note = "doi: 10.1016/j.cardfail.2010.06.060",
year = "2010",
month = "8",
day = "1",
doi = "10.1016/j.cardfail.2010.06.060",
language = "繁體中文",
volume = "16",
pages = "S17",
journal = "Journal of Cardiac Failure",
issn = "1071-9164",
publisher = "Elsevier",
number = "8",

}

TY - JOUR

T1 - LV-Only and LV-First Pacing Demonstrate Greater Improvements in Acute Hemodynamics Than Synchronous BiV Pacing in Heart Failure With Preserved Ejection Fraction

AU - Wang, Y.C.

AU - Yu, C.C.

AU - Klepfer, Ruth N.

AU - Hilpisch, Katherine

AU - Splett, Vince

AU - Lin, L.Y.

AU - Chiu, F.C.

AU - Tsai, C.T.

AU - Lai, L.P.

AU - Hwang, J.J.

AU - Lin, Jiunn-Lee

N1 - doi: 10.1016/j.cardfail.2010.06.060

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Background: Heart failure with a preserved ejection fraction (HFpEF) remains poorly understood with few options for treatment. Recent evidence identified regional delays in cardiac mechanical activation in HFpEF despite a narrow QRS and normal chamber size. We compared the acute effects of synchronous BiV pacing (VV0), BiV pacing with LV first (LVfirst) and LVonly (LVonly) pacing on mechanical dyssynchrony and hemodynamics in HFpEF. Methods: HF patients with EF O50% and echocardiographic evidence of dyssynchrony were studied during cardiac catheterization. Patients were instrumented with temporary pacing catheters in the RA, LV and RV, and paced in VDD mode with AV timing selected to optimize transmitral flow during simultaneous BiV pacing. A pressure catheter provided continuous LVand aortic pressure. LVonly, LVfirst and VV0 pacing were compared to normal sinus rhythm (NSR). During LVfirst pacing, theLV was stimulated 45 ms before the RV. Regional mechanical delay (RMD) was measured in all pacing modes and during NSR.RMD isthe time difference between the septal and lateral wall peak myocardial velocities. Results: Eleven patients participated (71 yo, 82% female, NYHA class of 2.5, BMI of 28 kg/m2). Patients had an EF of 74% and a narrow QRS (86 ms). LVonly and LVfirst significantly reduced systolic mechanical dyssynchrony, Ts-SD (standard deviation of time to peak systolic velocity of 12 ventricular segments) and RMD. However, E/E’ significantly decreased only during LVonly. Paradoxically, all three pacing modes also showed a significant increase in LVEDP. LVonly and LVfirst also demonstrated improvements in several measures of systolic function.

AB - Background: Heart failure with a preserved ejection fraction (HFpEF) remains poorly understood with few options for treatment. Recent evidence identified regional delays in cardiac mechanical activation in HFpEF despite a narrow QRS and normal chamber size. We compared the acute effects of synchronous BiV pacing (VV0), BiV pacing with LV first (LVfirst) and LVonly (LVonly) pacing on mechanical dyssynchrony and hemodynamics in HFpEF. Methods: HF patients with EF O50% and echocardiographic evidence of dyssynchrony were studied during cardiac catheterization. Patients were instrumented with temporary pacing catheters in the RA, LV and RV, and paced in VDD mode with AV timing selected to optimize transmitral flow during simultaneous BiV pacing. A pressure catheter provided continuous LVand aortic pressure. LVonly, LVfirst and VV0 pacing were compared to normal sinus rhythm (NSR). During LVfirst pacing, theLV was stimulated 45 ms before the RV. Regional mechanical delay (RMD) was measured in all pacing modes and during NSR.RMD isthe time difference between the septal and lateral wall peak myocardial velocities. Results: Eleven patients participated (71 yo, 82% female, NYHA class of 2.5, BMI of 28 kg/m2). Patients had an EF of 74% and a narrow QRS (86 ms). LVonly and LVfirst significantly reduced systolic mechanical dyssynchrony, Ts-SD (standard deviation of time to peak systolic velocity of 12 ventricular segments) and RMD. However, E/E’ significantly decreased only during LVonly. Paradoxically, all three pacing modes also showed a significant increase in LVEDP. LVonly and LVfirst also demonstrated improvements in several measures of systolic function.

U2 - 10.1016/j.cardfail.2010.06.060

DO - 10.1016/j.cardfail.2010.06.060

M3 - 文章

VL - 16

SP - S17

JO - Journal of Cardiac Failure

JF - Journal of Cardiac Failure

SN - 1071-9164

IS - 8

ER -