Lung cancer susceptibility and genetic polymorphism of DNA repair gene XRCC4 in Taiwan

Nan Yung Hsu, Hwei Chung Wang, Chung Hsing Wang, Chia Lin Chang, Chang Fang Chiu, Hong Zin Lee, Chia Wen Tsai, Da Tian Bau

研究成果: 雜誌貢獻文章

27 引文 斯高帕斯(Scopus)

摘要

Non-homologous end-joining (NHEJ) system is a major route in repairing double strand breaks (DSBs), and is important in maintaining the genome stability. The gene XRCC4 is a central role of the NHEJ system, and it is critical in carcinogenesis. In order to reveal the association between XRCC4 and lung cancer, we recruited 164 lung cancer patients and 649 healthy controls from central Taiwan, investigated seven novel polymorphic variants of XRCC4, includes C-1622T (rs7727691), G-1394T (rs6869366), G-652T (rs2075685), C-571T (rs2075686), intron3 DIP (rs28360071), S247A (rs3734091) and intron7 DIP (rs28360317), and analyzed the association of specific genotype with lung cancer susceptibility. The results showed that the XRCC4 G-1394T is significant in Taiwanese lung cancer and the GT genotype of G-1394T is an obvious risk factor of lung cancer susceptibility (P = 0.0049), and the G allele is a risky factor (P = 0.0087). As for XRCC4 C-1622T (rs7727691), G-652T (rs2075685), C-571T (rs2075686), intron3 DIP (rs28360071), S247A (rs3734091) and intron7 DIP (rs28360317) polymorphism sites, there was no difference in the distribution between the lung cancer and control groups. The analyzing results of joint effect for smoking habit and XRCC4 G-1394T polymorphism was that people with GT genotype and smoking habit present the highest risk of lung cancer than other groups (OR = 2.31, 95% CI = 1.43-3.72). The G allele of the XRCC4 G-1394T may be responsible for lung carcinogenesis and maybe useful in early detection and prevention of lung cancer.
原文英語
頁(從 - 到)159-165
頁數7
期刊Cancer Biomarkers
5
發行號4-5
DOIs
出版狀態已發佈 - 2009
對外發佈Yes

    指紋

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Genetics

引用此

Hsu, N. Y., Wang, H. C., Wang, C. H., Chang, C. L., Chiu, C. F., Lee, H. Z., Tsai, C. W., & Bau, D. T. (2009). Lung cancer susceptibility and genetic polymorphism of DNA repair gene XRCC4 in Taiwan. Cancer Biomarkers, 5(4-5), 159-165. https://doi.org/10.3233/CBM-2009-0617