摘要

Immunotherapy is a cancer therapy by enhancing T cell activity. Immune checkpoint, like PD-1/PD-L1, is a key mechanism to regulate T cell activity. The drugs for disrupting the PD-1-PD-L1 interaction are the present promising cancer therapy strategy. Current immunotherapy results in clinical trials show significant improvement in the survival rate in melanoma and lung cancer. However, Due to the high price of immunotherapy reagents, it is challenging to use preclinical experiments to find the appropriate drug dosage. Therefore, here we developed a microfluidic device combined with the following features. The first is highly biocompatible porous photo-initiated cross-linked hydrogel (GelMA) as a 3D culture model to mimic tumor tissue environment. The second is the peripheral channels to stimulate the immune cell environment in blood vessels. The third is the concentration gradient generator to achieve high-throughput multiple drug concentration testing. The results verified that cells could survive in GelMA, and the T cells could infiltrate into GelMA containing cancer cells. Furthermore, this Labchip can simultaneously detect the effects of three doses of drug counterparts on immune cells.
原文英語
主出版物標題21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021
發行者Institute of Electrical and Electronics Engineers Inc.
頁面1032-1035
頁數4
ISBN(電子)9781665412674
DOIs
出版狀態已發佈 - 六月 2021
事件21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021 - Virtual, Online, 美国
持續時間: 六月 20 2021六月 25 2021

出版系列

名字21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021

會議

會議21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021
國家/地區美国
城市Virtual, Online
期間6/20/216/25/21

ASJC Scopus subject areas

  • 電氣與電子工程
  • 機械工業
  • 控制和優化
  • 儀器

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