Lung cancer model on chip for drug testing

Kuo Wei Chang, Tushar Harishchandra Punde, Gaurav Prashant Pendharkar, Po Chen Shih, Yao Fei Chan, Kang Yun Lee, Ming Yan Chen, Cheng Hsien Liu

研究成果: 書貢獻/報告類型會議貢獻

摘要

In this paper we have simulated an in vitro lung cancer microenvironment by dielectrophoresis (DEP) patterning. Heterogeneous cells were patterned on the glass substrate, above which a microfluidic gradient is integrated to generate different concentration of target therapy drug (Iressa). Taking advantage of DEP pattern and microfluidic gradient, we designed a biochip to mimic the in vivo conditions. The influence of drug treatment for cell patterning is better than the non-patterned case as visualized in cell viability rate by MTT assay.

原文英語
主出版物標題2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
發行者Institute of Electrical and Electronics Engineers Inc.
頁面646-649
頁數4
ISBN(列印)9781479989553
DOIs
出版狀態已發佈 - 八月 5 2015
事件18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 - Anchorage, 美国
持續時間: 六月 21 2015六月 25 2015

其他

其他18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
國家美国
城市Anchorage
期間6/21/156/25/15

    指紋

ASJC Scopus subject areas

  • Instrumentation
  • Electrical and Electronic Engineering

引用此

Chang, K. W., Punde, T. H., Pendharkar, G. P., Shih, P. C., Chan, Y. F., Lee, K. Y., Chen, M. Y., & Liu, C. H. (2015). Lung cancer model on chip for drug testing. 於 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 (頁 646-649). [7181006] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/TRANSDUCERS.2015.7181006