Low serum carotene level and increased risk of ischemic heart disease related to long-term arsenic exposure

Yu Mei Hsueh, Wen Lin Wu, Ya Li Huang, Hung Yi Chiou, Chin Hsiao Tseng, Chien Jen Chen

研究成果: 雜誌貢獻文章

111 引文 (Scopus)

摘要

To elucidate the association between arsenic-related ischemic heart disease (ISHD) and serum antioxidant micronutrient level, residents aged 30 or older living in arseniasis-hyperendemic villages in Taiwan were recruited in a community-based health survey. A structured questionnaire was used to obtain a history of long-term exposure to arsenic through consuming artesian well water and fasting serum samples were also collected at the recruitment. A total of 74 patients affected with ISHD, who were diagnosed through both electrocardiography and Rose questionnaire interview, and 193 age-sex- matched healthy controls were selected for the examination of serum levels of micronutrients by high performance liquid chromatography (HPLC). There was a significant biological gradient between the risk of ISHD and the duration of consuming high-arsenic artesian well water. A significant reverse dose- response relationship with arsenic-related ISHD was observed for serum level of α- and β-carotene, but not for serum levels of retinol, lycopene and α- tocopherol. Multivariate analysis showed a synergistic interaction on arsenic-related ISHD between duration of consuming artesian well water and low serum carotene level. An increased risk of arsenic-related ISHD was also associated with hypertension and elevated body mass index, but not with serum lipid profile, cigarette smoking and alcohol drinking. The findings seem to suggest that arsenic-related ISHD has a pathogenic mechanism which is at least partially different from that of ISHD unrelated to long-term exposure to arsenic.

原文英語
頁(從 - 到)249-257
頁數9
期刊Atherosclerosis
141
發行號2
DOIs
出版狀態已發佈 - 十二月 1 1998

指紋

Arsenic
Carotenoids
Myocardial Ischemia
Water Wells
Serum
Micronutrients
Water
Tocopherols
Health Surveys
Vitamin A
Taiwan
Alcohol Drinking
Fasting
Electrocardiography
Body Mass Index
Multivariate Analysis
Antioxidants
Smoking
High Pressure Liquid Chromatography
Interviews

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

引用此文

Low serum carotene level and increased risk of ischemic heart disease related to long-term arsenic exposure. / Hsueh, Yu Mei; Wu, Wen Lin; Huang, Ya Li; Chiou, Hung Yi; Tseng, Chin Hsiao; Chen, Chien Jen.

於: Atherosclerosis, 卷 141, 編號 2, 01.12.1998, p. 249-257.

研究成果: 雜誌貢獻文章

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