摘要
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 2057-2064 |
| 頁數 | 8 |
| 期刊 | Internal Medicine |
| 卷 | 49 |
| 發行號 | 19 |
| DOIs | |
| 出版狀態 | 已發佈 - 2010 |
指紋
ASJC Scopus subject areas
- Internal Medicine
引用此文
Low serum acylated ghrelin levels are associated with the development of cardiovascular disease in hemodialysis patients. / Chou, Chia Chi; Bai, Chyi-Huey; Tsai, Shiow Chwen; Wu, Mai-Szu.
於: Internal Medicine, 卷 49, 編號 19, 2010, p. 2057-2064.研究成果: 雜誌貢獻 › 文章
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TY - JOUR
T1 - Low serum acylated ghrelin levels are associated with the development of cardiovascular disease in hemodialysis patients
AU - Chou, Chia Chi
AU - Bai, Chyi-Huey
AU - Tsai, Shiow Chwen
AU - Wu, Mai-Szu
PY - 2010
Y1 - 2010
N2 - Background Ghrelin has a protective effect on endothelial cells. Endothelial cell dysfunction is associated with cardiovascular disease (CVD) and CVD remains the leading cause of morbidity in hemodialysis (HD) patients. Acylated ghrelin (A-Ghr) is the functional form of ghrelin, so we hypothesized that A-Ghr is associated with the occurrence of CVD in HD patients. Methods We conducted a prospective cohort study in 412 HD patients. The cohort was sub-grouped into low and high A-Ghr groups according to the median A-Ghr level of 4.88 pg/mL. The association between the low/high A-Ghr groups and the incidence of CVD were analyzed. Results The HD patients in a low A-Ghr group had a greater risk of incidental CVD than those in a high A-Ghr ghrelin. This association remained significant after the adjustment for possible confounding factors, including age, gender, HD duration, BMI, diabetes, albumin, nPCR and Charlson's comorbidity index score. Conclusion It appears that a low serum A-Ghr level is associated with the development of CVD in HD patients.
AB - Background Ghrelin has a protective effect on endothelial cells. Endothelial cell dysfunction is associated with cardiovascular disease (CVD) and CVD remains the leading cause of morbidity in hemodialysis (HD) patients. Acylated ghrelin (A-Ghr) is the functional form of ghrelin, so we hypothesized that A-Ghr is associated with the occurrence of CVD in HD patients. Methods We conducted a prospective cohort study in 412 HD patients. The cohort was sub-grouped into low and high A-Ghr groups according to the median A-Ghr level of 4.88 pg/mL. The association between the low/high A-Ghr groups and the incidence of CVD were analyzed. Results The HD patients in a low A-Ghr group had a greater risk of incidental CVD than those in a high A-Ghr ghrelin. This association remained significant after the adjustment for possible confounding factors, including age, gender, HD duration, BMI, diabetes, albumin, nPCR and Charlson's comorbidity index score. Conclusion It appears that a low serum A-Ghr level is associated with the development of CVD in HD patients.
KW - Cardiovascular disease
KW - Ghrelin
KW - Hemodialysis
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U2 - 10.2169/internalmedicine.49.3047
DO - 10.2169/internalmedicine.49.3047
M3 - Article
C2 - 20930430
AN - SCOPUS:77958103211
VL - 49
SP - 2057
EP - 2064
JO - Internal Medicine
JF - Internal Medicine
SN - 0918-2918
IS - 19
ER -