Low plasma DHEA-S increases mortality risk among male hemodialysis patients

Heng Jung Hsu, Chiung Hui Yen, Chih Ken Chen, Kuang Hung Hsu, Cheng Cheng Hsiao, Chin Chan Lee, I. Wen Wu, Chiao Yin Sun, Chia Chi Chou, Ming Fang Hsieh, Chun Yu Chen, Chiao Ying Hsu, Chi Jen Tsai, Mai Szu Wu

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10 引文 斯高帕斯(Scopus)

摘要

Objective: The incidence of chronic kidney disease (CKD) is on the rise. CKD patients are at high risk of cardiovascular (CVD) and all-cause mortality. CKD patients have several endocrine disorders, including low levels of dehydroepiandrosterone sulfate (DHEA-S). In the general population, low levels of DHEA-S are associated with high CVD and all-cause mortality. The aim of this study was to analyze the prognostic value of plasma DHEA-S on the survival of CKD patients on hemodialysis. Method: This was a single-center prospective cohort study on two hundred CKD patients on hemodialysis, which assessed the prognostic value of plasma DHEA-S on their survival. Result: We found that plasma DHEA-S levels were negatively associated with age, and positively associated with dialysis duration and plasma creatinine, albumin, and phosphate levels in hemodialysis men. Elderly patients with co-morbidities (i.e. diabetes mellitus, congestive heart failure, and chronic obstructive pulmonary disease), poorer fluid control which was evaluated by higher cardiothoracic ratio, and low plasma creatinine and albumin levels seemed to have poor prognosis in hemodialysis men. Furthermore, low plasma DHEA-S levels were significantly associated with CVD-related [hazard ratio (HR) = 3.877; P=0.021], non-CVD-related (HR = 3.522; P=0.016), and all-cause mortality (HR = 3.667; P=0.001) in hemodialysis men. But low plasma DHEA-S levels were not significantly associated with CVD-related, non-CVD-related, and all-cause mortality in hemodialysis women. Multivariate Cox regression analysis suggested that low plasma DHEA-S levels are significantly and independently associated with all-cause mortality in hemodialysis men (HR = 2.933; P=0.033). Conclusion: The study suggested that low plasma DHEA-S was independently and significantly associated with all-cause mortality in CKD hemodialysis men.

原文英語
頁(從 - 到)950-957
頁數8
期刊Experimental Gerontology
47
發行號12
DOIs
出版狀態已發佈 - 十二月 2012

ASJC Scopus subject areas

  • 生物化學
  • 老化
  • 分子生物學
  • 遺傳學
  • 內分泌
  • 細胞生物學

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