Low concentrations of dehydroepiandrosterone sulfate are associated with depression and fatigue in patients with non-small-cell lung cancer after chemotherapy

Yu Hung Fang, Meng Jer Hsieh, Ming Szu Hung, Yu Ching Lin, Liang Tseng Kuo, Mong Liang Lu, Bor Show Tzang, Vincent Chin Hung Chen

研究成果: 雜誌貢獻文章同行評審

摘要

Background: Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) concentrations were reported to decrease in patients with advanced cancer. However, the clinical significance of DHEA and DHEAS concentrations in patients with NSCLC receiving chemotherapy (CT) has not been sufficiently documented. Objective: To evaluate the correlation between mental health and hormone concentrations on patients with advanced non-small-cell lung cancer (NSCLC). Materials and Methods: The present study was a cross-sectional analysis based on a self-reported psychological investigation. Salivary samples were collected from 22 patients with advanced NSCLC after CT and 17 healthy controls. The concentrations of DHEA, DHEAS, and cortisol were analyzed to investigate their associations with the results of self-reported questionnaires on psychological health. Results: Patients with advanced NSCLC exhibited significantly higher Patient Health Questionnaire (PHQ-9) and Startle, Physiological arousal, Anger, and Numbness-Chinese version (SPAN-C) scores, poorer health conditions, lower sleep quality, and more severe fatigue after CT than did healthy controls, and salivary concentrations of DHEA and DHEAS were significantly lower among patients after CT than among controls. DHEAS concentrations were negatively associated with depression scores (PHQ-9, r = −0.496, P = 0.019) and fatigue scores (Brief Fatigue Inventory-Taiwan, r = −0.562, P = 0.006). Conclusion: Patients with advanced NSCLC after CT had lower DHEA and DHEAS concentrations than did controls. Lower DHEAS concentrations were associated with higher fatigue and depression scores.

原文英語
頁(從 - 到)2103-2109
頁數7
期刊Neuropsychiatric Disease and Treatment
16
DOIs
出版狀態已發佈 - 2020

ASJC Scopus subject areas

  • 精神病學和心理健康
  • 生物精神病學

指紋

深入研究「Low concentrations of dehydroepiandrosterone sulfate are associated with depression and fatigue in patients with non-small-cell lung cancer after chemotherapy」主題。共同形成了獨特的指紋。

引用此