Loss to followup in HIV-infected patients from Asia-pacific region: Results from TAHOD

Jialun Zhou, Junko Tanuma, Romanee Chaiwarith, Christopher K.C. Lee, Matthew G. Law, Nagalingeswaran Kumarasamy, Praphan Phanuphak, Yi Ming A. Chen, Sasisopin Kiertiburanakul, Fujie Zhang, Saphonn Vonthanak, Rossana Ditangco, Sanjay Pujari, Jun Yong Choi, Tuti Parwati Merati, Evy Yunihastuti, Patrick C.K. Li, Adeeba Kamarulzaman, Van Kinh Nguyen, Thi Thanh Thuy PhamPoh Lian Lim

研究成果: 雜誌貢獻文章同行評審

31 引文 斯高帕斯(Scopus)


This study examined characteristics of HIV-infected patients in the TREAT Asia HIV Observational Database who were lost to follow-up (LTFU) from treatment and care. Time from last clinic visit to 31 March 2009 was analysed to determine the interval that best classified LTFU. Patients defined as LTFU were then categorised into permanently LTFU (never returned) and temporary LTFU (re-entered later), and these groups compared. A total of 3626 patients were included (71% male). No clinic visits for 180 days was the best-performing LTFU definition (sensitivity 90.6%, specificity 92.3%). During 7697 person-years of follow-up, 1648 episodes of LFTU were recorded (21.4 per 100-person-years). Patients LFTU were younger (P = 0.002), had HIV viral load ≥500 copies/mL or missing (P = 0.021), had shorter history of HIV infection (P = 0.048), and received no, single- or double-antiretroviral therapy, or a triple-drug regimen containing a protease inhibitor (P < 0.001). 48% of patients LTFU never returned. These patients were more likely to have low or missing haemoglobin (P < 0.001), missing recent HIV viral load (P < 0.001), negative hepatitis C test (P = 0.025), and previous temporary LTFU episodes (P < 0.001). Our analyses suggest that patients not seen at a clinic for 180 days are at high risk of permanent LTFU, and should be aggressively traced.
期刊AIDS Research and Treatment
出版狀態已發佈 - 12月 1 2012

ASJC Scopus subject areas

  • 免疫學和過敏
  • 皮膚科
  • 公共衛生、環境和職業健康
  • 傳染性疾病


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