Longevity and lifespan control in mammals: Lessons from the mouse

Yi Fan Chen, Chia Yu Wu, Cheng Heng Kao, Ting Fen Tsai

研究成果: 雜誌貢獻回顧型文獻同行評審

34 引文 斯高帕斯(Scopus)

摘要

Aging, which affects all organ systems, is one of the most complex phenotypes. Recent discoveries in long-lived mutant mice have revealed molecular mechanisms of longevity in mammals which may contribute to our understanding of why humans age. These mutations include naturally occurring spontaneous mutations, and those of mice genetically modified by modern genomic technologies. It is generally believed that the most fundamental mechanisms of aging are evolutionarily conserved across species. The following types of longevity mechanisms have been intensively studied: suppression of the somatotropic (growth hormone/insulin-like growth factor 1) axis, decreased metabolism and increased resistance of oxidative stress, reduced insulin secretion and increased insulin sensitivity, and delayed reproductive maturation and reduced fertility. In addition, many of the mutations have a sex-dependent effect on lifespan, and when present in different genetic backgrounds, the effects of the same gene mutation can vary considerably. The present review discusses these phenotypic variations as well as describing the known longevity genes in long-lived mutant mice and the molecular mechanisms specifying longevity. We anticipate that these mouse studies will ultimately provide clues about how to delay the aging and prolong lifespan, and help to develop therapies for healthier human aging.
原文英語
期刊Ageing Research Reviews
9
發行號SUPPL.
DOIs
出版狀態已發佈 - 十一月 2010
對外發佈

ASJC Scopus subject areas

  • 老化
  • 生物化學
  • 生物技術
  • 分子生物學
  • 神經內科

指紋

深入研究「Longevity and lifespan control in mammals: Lessons from the mouse」主題。共同形成了獨特的指紋。

引用此