Long-term continuous exposure to static magnetic field reduces popolysaccharide-induced cytotoxicity of fibroblasts

Che Tong Lin, Sheng Yang Lee, Chun Yang Chen, Chi An Chen, Chih Ping Lin, Haw Ming Huang

研究成果: 雜誌貢獻文章

10 引文 斯高帕斯(Scopus)

摘要

Purposes: Lipopolysaccharide (LPS) is one of the major substances initiating the immune host response in microbial infections that results in cytotoxicity. In terms of treatment of the immune response, research has been conducted on physical environments that can reduce LPS-induced damage. In this experiment, a long-term continuous static magnetic field (SMF) was used as a physical resource to reduce LPS-induced immune host response. Materials and methods: Cultured fibroblasts were challenged with LPS to initiate an inflammatory reaction. Cell viability and various proinflammatory cytokine levels were detected and compared between SMF and sham-exposed groups. Results: Our in vitro study revealed that, with LPS challenge, fibroblasts continuously exposed to a 0.4-T SMF for 12 h demonstrated higher cell viability compared to unexposed analogs. From cytokine test, the levels of LPS-induced interleukin-1β (IL-1β) in the SMF-exposed groups were significantly lower relative to their unexposed counterparts (p <0.05). By contrast, SMF exposure tended to increase the level of LPS-induced IL-1 receptor antagonist (IL-1Ra) and IL-6. Conclusions: Our results suggest that SMF stimulation inhibits LPS-induced cytotoxicity through reduction of proinflammatory cytokines and increase in anti-inflammatory cytokines of NIH-3T3 cells.
原文英語
頁(從 - 到)219-226
頁數8
期刊International Journal of Radiation Biology
84
發行號3
DOIs
出版狀態已發佈 - 2008

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Nuclear Energy and Engineering
  • Radiation

指紋 深入研究「Long-term continuous exposure to static magnetic field reduces popolysaccharide-induced cytotoxicity of fibroblasts」主題。共同形成了獨特的指紋。

  • 引用此