Long-term arsenic exposure and ischemic heart disease in arseniasis-hyperendemic villages in Taiwan

Chin Hsiao Tseng, Choon Khim Chong, Ching Ping Tseng, Yu Mei Hsueh, Hung Yi Chiou, Ching Chung Tseng, Chien Jen Chen

研究成果: 雜誌貢獻文章

180 引文 斯高帕斯(Scopus)

摘要

The association between long-term arsenic exposure and peripheral vascular disease has been well documented in our previous epidemiologic studies. The purpose of this study was to evaluate whether long-term arsenic exposure could be associated with ischemic heart disease (IHD). A total of 462 subjects living in the blackfoot disease-hyperendemic villages along the southwestern coast of Taiwan and characterized by long-term arsenic exposure from drinking artesian well water was studied. The subjects were recruited from an epidemiologic cohort who participated in a health examination. IHD was diagnosed by coding the resting electrocardiograms with the Minnesota code. History of arsenic exposure was estimated through information obtained from a personal interview according to a structured questionnaire and the arsenic content in artesian well water of the villages. Cumulative arsenic exposure (CAE) was calculated as the sum of the products multiplying the arsenic concentration in artesian well water (mg/l) by the duration of drinking the water (years) in consecutive periods of living in the different villages. Among the subjects, 78 cases (16.9%) were diagnosed as having IHD. The prevalence rates of IHD for the age groups of 30-39, 40-49, 50-59, and ≥60 years were 4.9, 7.5, 16.8, and 30.7%, respectively (P

原文英語
頁(從 - 到)15-21
頁數7
期刊Toxicology Letters
137
發行號1-2
DOIs
出版狀態已發佈 - 一月 31 2003

ASJC Scopus subject areas

  • Toxicology

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